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A Review on Novel Drug Targets and Future Directions for COVID-19 Treatment

Authors Wondmkun YT, Mohammed OA

Received 12 June 2020

Accepted for publication 4 August 2020

Published 25 August 2020 Volume 2020:14 Pages 77—82

DOI https://doi.org/10.2147/BTT.S266487

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Professor Shein-Chung Chow


Yohannes Tsegyie Wondmkun,1 Ousman Ahmed Mohammed2

1Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia; 2College of Health Sciences, Woldia University, Woldia, Ethiopia

Correspondence: Yohannes Tsegyie Wondmkun
Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Churchill Avenue, P.O. Box 1176, Addis Ababa, Ethiopia
Email yohannes.tsegyie@aau.edu.et

Abstract: Severe acute respiratory syndrome coronavirus-2 causes coronavirus disease-19 (COVID-19) that spreads quickly in the world. Considering the impact of this pandemic, researchers have been racing to understand the peculiar nature of the virus and the pathogenesis of the disease to uncover possible drug targets, effective therapeutic agents, and vaccines. Accordingly, numerous drug targets are identified by scientists. Among them, structural glycoproteins, virulence factors, host-specific receptors and enzymes, non-structure proteins, the Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway, and pro-inflammatory cytokines are discussed herein. This review summarizes the promising drug targets for COVID-19, and highlights antiviral strategies which depend on molecular interactions between viral small molecules and host biologic machinery for repurposing the available clinical drugs. In addition, it gives a strong rational basis for the ongoing discovery of new drugs and vaccines.

Keywords: COVID-19, drug targets, SARS-COV-2, non-structural proteins, structural proteins

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