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A review on current nanomaterials and their drug conjugate for targeted breast cancer treatment

Authors Lee JJ, Saiful Yazan L, Che Abdullah CA

Received 10 November 2016

Accepted for publication 11 January 2017

Published 27 March 2017 Volume 2017:12 Pages 2373—2384

DOI https://doi.org/10.2147/IJN.S127329

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Thomas Webster


Joanna Jinling Lee,1 Latifah Saiful Yazan,2 Che Azurahanim Che Abdullah3

1Laboratory of Molecular Biomedicine, Institute of Bioscience, 2Department of Biomedical Science, Faculty of Medicine and Health Sciences, 3Department of Physics, Faculty of Science, Universiti Putra Malaysia, Selangor, Malaysia

Abstract: Breast cancer is the most common malignancy worldwide, especially among women, with substantial after-treatment effects. The survival rates of breast cancer have decreased over the years even with the existence of various therapeutic strategies, specifically, chemotherapy. Clinical drugs administered for breast cancer appear to be non-targeting to specific cancer sites leading to severe side effects and potentially harming healthy cells instead of just killing cancer cells. This leads to the need for designing a targeted drug delivery system. Nanomaterials, both organic and inorganic, are potential drug nanocarriers with the ability of targeting, imaging and tracking. Various types of nanomaterials have been actively researched together with their drug conjugate. In this review, we focus on selected nanomaterials, namely solid-lipid, liposomal, polymeric, magnetic nanoparticles, quantum dots, and carbon nanotubes and their drug conjugates, for breast cancer studies. Their advantages, disadvantages and previously conducted studies were highlighted.

Keywords: breast cancer, therapeutic strategies, nanomedicine, advantages, disadvantages

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