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A review about biomarkers for the investigation of vascular function and impairment in diabetes mellitus

Authors Derosa G, Maffioli P

Received 21 June 2015

Accepted for publication 9 August 2016

Published 9 November 2016 Volume 2016:12 Pages 415—419

DOI https://doi.org/10.2147/VHRM.S64460

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 3

Editor who approved publication: Dr Daniel Duprez


Giuseppe Derosa,1 Pamela Maffioli2

1Centre of Diabetes and Metabolic Diseases, Department of Internal Medicine and Therapeutics, University of Pavia and Fondazione IRCCS Policlinico S. Matteo, 2School in Experimental Medicine, University of Pavia, Pavia, Italy

Abstract: The aim of this review was to analyze the main biomarkers of vascular function and impairment in patients with type 2 diabetes. Medline, SCOPUS, Web of Science, and Google Scholar databases were searched. We concluded that proatherogenic adhesion molecules (soluble intercellular adhesion molecule-1, soluble vascular adhesion molecule-1, and soluble E selectin) and inflammatory cytokines (high-sensitivity C-reactive protein, interleukin-6, and tumor necrosis factor-α) were elevated in type 2 diabetes mellitus. Their increased expression and release contribute to the accelerated atherogenesis typical of these patients. For these reasons, the early identification of high levels of these biomarkers will help to establish new strategies to reduce cardiovascular complications.

Keywords: biomarkers, vascular function, type 2 diabetes mellitus

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