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A Response to Article “Distribution of Mcr-1 Harboring Hypervirulent Klebsiella pneumoniae in Clinical Specimens and Lytic Activity of Bacteriophage KpnM Against Isolates” [Response to Letter]
Authors Aslam B, Khurshid M , Ahmad M, Baloch Z
Received 24 October 2022
Accepted for publication 28 October 2022
Published 11 November 2022 Volume 2022:15 Pages 6601—6602
Bilal Aslam,1 Mohsin Khurshid,1 Moeed Ahmad,1 Zulqarnain Baloch2
1Department of Microbiology, Government College University, Faisalabad, Pakistan; 2Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, People’s Republic of China
Correspondence: Bilal Aslam, Department of Microbiology, Government College University Faisalabad, Faisalabad, Pakistan, Email [email protected]
View the original paper by Dr Aslam and colleagues
This is in response to the Letter to the Editor
Dear editor
We acknowledge the effort made by the author to craft the response to our recent publication in infection and drug resistance.1 We are pleased that the author appreciated our work and found the results of the study promising to fight antibiotic resistance and resistant superbugs like Klebsiella pneumoniae. In addition to that, the author raised some fair queries regarding the methods and suggested possible explications. For instance, though we have characterized the isolates in the present investigation, we mentioned only the string test as a phenotypic test to characterize the hypervirulent isolates, which served the purpose of the study.2 However, as the authors suggested that mentioning the detailed molecular identification of the hypervirulent strains could be a better procedure. Taking it together, we appreciate the author for valuable suggestions and future directions to decipher the molecular mechanisms involved in the lytic activity of bacteriophage KpnM, which we shall consider in our imminent research plans.3
Disclosure
All the authors reported that there is no conflict of interest in this communication.
References
1. Aslam B, Siddique MH, Siddique AB, et al. Distribution of mcr-1 harboring hypervirulent Klebsiella pneumoniae in clinical specimens and lytic activity of bacteriophage KpnM against isolates. Infect Drug Resist. 2022;15:5795–5811. doi:10.2147/IDR.S374503
2. Shon AS, Bajwa RP, Russo TA. Hypervirulent (hypermucoviscous) Klebsiella pneumoniae: a new and dangerous breed. Virulence. 2013;4(2):107–118. doi:10.4161/viru.22718
3. Aslam B, Arshad MI, Aslam MA, et al. Bacteriophage proteome: insights and potentials of an alternate to antibiotics. Infect Dis Ther. 2021;10(3):1171–1193. doi:10.1007/s40121-021-00446-2
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