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A network pharmacology approach to determine the synergetic mechanisms of herb couple for treating rheumatic arthritis

Authors Xu XX, Bi JP, Ping L, Li P, Li F

Received 8 January 2018

Accepted for publication 12 March 2018

Published 24 April 2018 Volume 2018:12 Pages 967—979

DOI https://doi.org/10.2147/DDDT.S161904

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Qiongyu Guo


Xi-xi Xu,1 Jian-ping Bi,2 Li Ping,3 Ping Li,1 Fei Li1,4

1State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, People’s Republic of China; 2Orthopedics Department, Shandong Provincial Traditional Chinese Medical Hospital, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, People’s Republic of China; 3Center for Drug Safety Evaluation and Research, Zhejiang University, Hangzhou, People’s Republic of China; 4School of Pharmacy, Xinjiang Medical University, Urumqi, People’s Republic of China

Purpose: The purpose of this study was to investigate the therapeutic mechanism(s) of Clematis chinensis Osbeck/Notopterygium incisum K.C. Ting ex H.T (CN).
Methods: A network pharmacology approach integrating prediction of ingredients, target exploration, network construction, module partition and pathway analysis was used.
Results: This approach successfully helped to identify 12 active ingredients of CN, interacting with 13 key targets (Akt1, STAT3, TNFsf13, TP53, EPHB2, IL-10, IL-6, TNF, MAPK8, IL-8, RELA, ROS1 and STAT4). Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis indicated that CN-regulated pathways were mainly classified into signal transduction and immune system.
Conclusion: The present work may help to illustrate the mechanism(s) of action of CN, and it may provide a better understanding of antirheumatic effects.

Keywords: targets prediction, pathways analysis, action mechanism, Clematis chinensis Osbeck, Notopterygium incisum K.C. Ting ex H.T. Chang

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