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A global quantitative survey of hemostatic assessment in postpartum hemorrhage and experience with associated bleeding disorders

Authors James AH, Cooper DL, Paidas MJ

Received 11 January 2017

Accepted for publication 9 May 2017

Published 3 July 2017 Volume 2017:9 Pages 477—485


Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Professor Elie Al-Chaer

Andra H James,1 David L Cooper,2 Michael J Paidas3

1Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Duke University, Durham, NC, 2Clinical, Medical and Regulatory Affairs, Novo Nordisk Inc., Plainsboro, NJ, 3Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale Women and Children’s Center for Blood Disorders and Preeclampsia Advancement, Yale University, New Haven, CT, USA

Purpose: Coagulopathy may be a serious complicating or contributing factor to postpartum hemorrhage (PPH), and should be promptly recognized to ensure proper bleeding management. This study aims to evaluate the approaches of obstetrician-gynecologists worldwide towards assessing massive PPH caused by underlying bleeding disorders.
Methods: A quantitative survey was completed by 302 obstetrician-gynecologists from 6 countries (the UK, France, Germany, Italy, Spain, and Japan). The survey included questions on the use of hematologic laboratory studies, interpretation of results, laboratory’s role in coagulation assessments, and experience with bleeding disorders.
Results: Overall, the most common definitions of “massive” PPH were >2,000 mL (39%) and >1,500 mL (34%) blood loss. The most common criteria for rechecking a “stat” complete blood count and for performing coagulation studies were a drop in blood pressure (73%) and ongoing visible bleeding (78%), respectively. Laboratory coagulation (prothrombin time/activated partial thromboplastin time [PT/aPTT]) and factor VIII/IX assays were performed on-site more often than were mixing studies (laboratory coagulation studies, 93%; factor VIII/IX assays, 63%; mixing studies, 22%). Most commonly consulted sources of additional information were colleagues within one’s own specialty (68%) and other specialists (67%). Most respondents had consulted with a hematologist (78%; least, Germany [56%]; greatest, UK [98%]). The most common reason for not consulting was hematologist unavailability (44%). The most commonly reported thresholds for concern with PT and aPTT were 13 to 20 seconds (36%) and 30 to 45 seconds (50%), respectively. Most respondents reported having discovered an underlying bleeding disorder (58%; least, Japan [35%]; greatest, Spain [74%]).
Conclusion: Global survey results highlight similarities and differences between countries in how PPH is assessed and varying levels of obstetrician-gynecologist experience with identification of underlying bleeding disorders and engagement of hematology consultants. Opportunities to improve patient management of PPH associated with bleeding disorders include greater familiarity with interpreting PT/aPTT test results and identification of and consistent consultation with hematologists with relevant expertise.

Keywords: postpartum hemorrhage, acquired hemophilia, bleeding disorders, hematologist, coagulation studies


Although postpartum hemorrhage (PPH) is most often a consequence of obstetric factors (eg, atony) or surgical bleeding,16 coagulopathy may be a complicating or contributing factor and may impair attempts to control bleeding if not promptly recognized. Types of coagulopathies include dilutional or consumptive states that may develop as a consequence of resuscitative measures for massive PPH,4,7 regardless of the precipitating cause, and preexisting acquired or congenital coagulation disorders that may underlie immediate or delayed PPH.4 Acquired disorders that may occur during or after pregnancy include quantitative platelet disorders8 such as HELLP (hemolysis, elevated liver enzymes, low platelets) and acquired hemophilia, a rare condition that is characterized by alloantibodies against coagulation factors (most often factor VIII) and is associated with pregnancy in 2% to 29% of cases.914 Among congenital coagulation disorders, von Willebrand disease (VWD), hemophilia carriage (factor VIII or IX deficiency), factor XI deficiency, various rare bleeding disorders (eg, fibrinogen, factors II, V, VII, and X deficiencies), and severe platelet function disorders of Glanzmann’s thrombasthenia and Bernard–Soulier syndrome are associated with higher-than-expected rates of PPH.15 PPH may be notably delayed in both congenital bleeding disorders and acquired hemophilia, with the latter manifesting as late as 117 days after delivery.4,14,15 Acquired hemophilia is a hemorrhagic disorder often presenting with diffuse soft tissue bleeding and exhibiting refractoriness to factor VIII therapy, and potentially causing life-threatening bleeding symptoms.9,11,16,17 Because of the extreme rarity of this condition, many obstetrician-gynecologists may be unfamiliar with the specialized laboratory assessments necessary to confirm the diagnosis.

Prompt diagnosis of acquired and congenital coagulation disorders requires early and consistent hemostatic assessment; however, recent survey data highlight variability in how different specialists in the USA approach the bleeding patient, and the extent to which health care professionals investigate reasons for bleeding rather than focusing only on the location of bleeding.18,19 In a report published recently in the International Journal of Women’s Health, data were presented from a quantitative survey assessing practice patterns of obstetrician-gynecologists in the USA regarding PPH management, including assessment for contributing coagulopathy.18 Nearly all (98%) of those surveyed reported experience with what they defined as “massive” or “severe” PPH in the preceding 5 years, although responses revealed variability in definitions of massive PPH, when to obtain coagulation tests, how to interpret test results, and in experience with consulting hematology for identified bleeding disorders. Approximately half of the participants had discovered an underlying bleeding disorder in a patient with PPH, yet fewer than half would check coagulation studies for any criteria other than ongoing visible bleeding in the setting of PPH, including refractoriness to pharmacologic and surgical treatments for PPH or hemodynamic perturbations. In addition, the likelihood of hematologist consultation for PPH was low; 42% of respondents had never consulted a hematologist for this purpose, and 34% had done so only 1 or 2 times. These findings revealed potential areas for improved practice in managing massive PPH, such as earlier and more consistent assessment and monitoring of coagulation studies and consultation with a hematologist.

Prompted by the results in the USA, here we report the findings of a similar quantitative survey of obstetrician-gynecologists from 6 other countries chosen to represent diverse health care systems. This study aimed to identify similarities and differences in the approach of obstetrician-gynecologists and other specialists towards assessment of the bleeding patient with PPH, with a specific focus on experience with identification of an underlying congenital or acquired bleeding disorder.

Materials and methods

Similar to the US survey previously reported,18 obstetrician-gynecologists were recruited from the UK, France, Germany, Italy, Spain, and Japan. The survey was translated into the local language in each country. Physicians were randomly sampled from consulting group lists of registered physicians, and they had to be actively practicing to be included. Sampled physicians were invited to participate via email and provided with a URL and password for one-time use to the secure survey website. The online survey took ~25 minutes to complete, was open for 4 weeks, and was closed for each country at 50 responses. Subjects were compensated for their participation, with amounts ranging from $56 (France, Germany, Japan, and Italy) to $101 (UK). The survey included questions on the use of specific hematologic laboratory studies, the interpretation of laboratory results, the roles of respondents’ on-site laboratories in facilitating those processes, and respondents’ experience with discovering underlying bleeding disorders, including acquired hemophilia. This physician survey was exempt from Institutional Review Board approval, as no private or protected information or biological specimens were elicited, and data collection did not allow for linking responses back to participating physicians or any individual patients.


Survey respondents included 302 obstetrician-gynecologists from a total of 6 countries: the UK (n=50), France (n=50), Germany (n=50), Italy (n=50), Spain (n=50), and Japan (n=52). The majority of respondents were men (75%), and the overall mean age was 46.2 years. Respondents had spent a mean of 18.9 years in practice. The majority of respondents (60%) practiced in a hospital-based setting; 27% practiced in an office and 12% reported practicing in both hospital-based and office settings.

Overall, the most common definition of “massive” PPH was >2,000 mL of blood loss (39%); 34% defined massive PPH as >1,500 mL of blood loss and 23% as >1,000 mL. Compared to other countries, respondents from the UK exhibited highest use of the definition >2,000 mL of blood loss (54%), and those from France reported highest use of the definition >1,000 mL of blood loss (32%). The reported use of various management strategies for PPH across regions is shown in Figure 1. Of uterotonic strategies (Figure 1A), a majority of respondents reported having used methylergonovine (64%); fewer respondents had used misoprostol (48%) or carboprost tromethamine (46%). Of surgical strategies (Figure 1B), the most commonly reported technique overall was hysterectomy (82%). The use of several surgical strategies varied substantially between regions; in particular, reported rates of Bakri balloon and B-Lynch or similar compression suture use were higher in the UK than overall (Bakri balloon, 88% vs 44%; B-Lynch or similar compression suture, 92% vs 47%), and rates of interventional radiology with embolization were higher in France than overall (84% vs 51%). Among blood/factor products (Figure 1C), the most common therapies were packed red blood cells (88%) and fresh frozen plasma (82%).

Figure 1 Strategies used for the management of postpartum hemorrhage: uterotonics (A); surgery (B); and blood/factor products (C).

The most commonly reported criteria for rechecking a “stat” complete blood count were a drop in blood pressure (73%), ongoing visible bleeding (72%), tachycardia (70%), and an estimated 1,000 mL of blood loss (63%); the most common criteria for checking coagulation studies were ongoing visible bleeding (78%), a drop in hematocrit/hemoglobin (58%), and a drop in blood pressure (57%). Laboratory coagulation studies and factor VIII/IX studies were most often performed on-site at participants’ institutions, rather than being sent to an external lab (coagulation studies, 93% overall; country-specific responses ranged from 84% [France] to 98% [UK and Germany]; factor VIII/IX studies, 63% overall; country-specific responses ranged from 21% [Japan] to 76% [UK]). Mixing studies (in which plasma from an individual without any hemostatic abnormalities is mixed in a 1:1 ratio with plasma from the patient of interest and tested via PT or aPTT to investigate the presence of inhibitors) were less frequently performed on-site (22% overall; country-specific responses ranged from 10% [UK] to 44% [Japan]). In a majority of cases in which coagulation studies had been performed, abnormal results were flagged (overall mean, 71%; country-specific responses ranged from 42% [Italy] to 89% [Germany]). In most cases, normal ranges were also provided for reference (64% overall).

The resources that respondents most commonly reported consulting for additional information were colleagues within their own specialty (68%), other specialists (67%), and PubMed (54%). Most respondents reported having consulted with a hematologist for PPH (overall, 78%; country-specific responses ranged from 56% [Germany] to 98% [UK]) (Figure 2A); overall, 30% of respondents reported having consulted with a hematologist 5 or more times (country-specific responses ranged from 12% [Germany] to 76% [UK]). Reported reasons for not consulting with hematology included a hematologist not always being available (44%), a sense of responsibility towards diagnosing and treating such patients oneself (33%), comfort with handling (diagnosing and treating) such patients (20%), and not having a hematologist on staff at the hospital (19%) (Figure 2B).

Figure 2 Frequency of hematology consultations (A) and reasons for not consulting hematology (B).

When asked at what level prothrombin time (PT) results would begin to cause concern, most respondents indicated a threshold of 13 to 20 seconds (36%) or 21 to 49 seconds (32%); 7% indicated a threshold of <10 seconds, 6% indicated 10 to 12 seconds, and 18% indicated ≥50 seconds (Figure 3A). Of individual countries, Spain was associated with the greatest level of sensitivity to an elevated PT (72% reported a threshold of ≤20 seconds), and Germany with the lowest sensitivity (20% reported a threshold of ≤20 seconds). When asked at what level activated partial thromboplastin time (aPTT) results would begin to cause concern, most respondents indicated a threshold of 30 to 45 seconds (50%) or <30 seconds (20%); 13% indicated a threshold of 46 to 59 seconds, 14% indicated 60 to 75 seconds, and 3% indicated ≥76 seconds (Figure 3B). The UK and Spain were associated with the greatest level of sensitivity to an elevated aPTT (82% of each reported a threshold of ≤45 seconds), and Germany with the lowest sensitivity (52% reported a threshold of ≤45 seconds). Respondents reported little experience with mixing studies; overall, only 11% had ordered mixing studies (country-specific responses ranged from 6% [Italy] to 18% [Japan]). Respondents also reported little familiarity with mixing studies; on a scale from 1 (“not at all familiar”) to 7 (“very familiar”), most respondents indicated a level of 1 to 2 (78%), and 20% reported a level of 3 to 5. Across all countries, Japan was associated with the greatest level of familiarity with mixing studies (52% reported a level of 3 to 5 and 10% reported a level of 6 to 7).

Figure 3 PT (A) and aPTT (B) thresholds for concern.
Abbreviations: aPTT, activated partial thromboplastin time; PT, prothrombin time.

A majority of respondents reported having discovered an underlying bleeding disorder (58%); country-specific responses ranged from 35% (Japan) to 74% (Spain) (Table 1). A majority (54%) of respondents were interested in learning more about bleeding disorders; greatest interest was in Spain (70% rated 6–7 of 7) and UK (66%), and least in Japan (27%). Preferred ways to learn more included journals or publications (54%), online (38%), and national/regional conferences (33%).

Table 1 Discovery of bleeding disorders and experience with acquired hemophilia among obstetrician-gynecologists
Note: *Among obstetrician-gynecologists who have discovered an underlying bleeding disorder.

Among those who had discovered a bleeding disorder, while most probably had encountered disseminated intravascular coagulation or other frequent causes of coagulopathy, exposure to rare disorders was likely more limited. For example, despite post-partum bleeding being cited as a common presentation of acquired hemophilia in women of childbearing age, few respondents reported having seen it (overall, 23% reported encountering acquired hemophilia; country-specific responses ranged from 0% [Japan] to 43% [Germany]). Some respondents had never heard of acquired hemophilia or knew the name only (36%); 20% reported having some or a lot of knowledge regarding acquired hemophilia.


The results of this global quantitative survey expand upon findings from the previously published survey of US obstetrician-gynecologists by capturing responses across different health care delivery systems. Overall, the global sample was similar to the US sample regarding mean age and mean years in practice. US respondents had a higher threshold for defining massive PPH, with 64% of US respondents defining massive PPH as >2,000 mL blood loss. Comparatively, 39% of the overall global sample defined massive PPH as >2,000 mL blood loss, while a roughly equal percentage (34%) used a threshold of >1,500 mL. Similar percentages of the overall global and US samples reported using packed red blood cells and fresh frozen plasma for PPH, but nearly half of the overall global sample used clotting factor(s), compared with only one-quarter of the US sample. Cryoprecipitate was used by more physicians in the US sample (74%) than in the overall global sample (31%).

Similar to the US survey, the most common threshold for checking coagulation studies was ongoing visible bleeding. Whereas fewer than half of respondents in the US survey selected any other threshold for checking coagulation studies, nearly 60% of participants in the global survey identified tachycardia and an estimated blood loss of 1,000 mL as additional triggers for ordering coagulation studies in this setting. Nearly all respondents in both the global and US surveys reported that coagulation studies were performed on-site at their practice locations, indicating that the availability of such testing was likely not a barrier towards obtaining results.

The interpretation of coagulation test results was an additional factor assessed in this survey. Overall, the PT and aPTT thresholds most commonly identified as indicating concern (13 to 20 seconds and 30 to 45 seconds, respectively), were consistent with reference ranges (typically 10 to 12 seconds for PT and 24 to 37 seconds for aPTT),20,21 although reference ranges are known to be variable and depend on the laboratory performing the test, due in part to variability in the reagents, analyzer instruments, and calibration. Outliers regarding PT thresholds included the German cohort, half of whom selected a higher range of 21 to 40 seconds as cause for concern, and the French cohort, the greatest percentage (40%) of whom identified a very high threshold of ≥50 seconds. For aPTT, the most significant outlier was the Italian cohort, the highest percentage (38%) of whom identified a low threshold of ≤30 seconds.

Ensuring the appropriate handling of abnormal test results is an important aspect of diagnosis and was also addressed in the survey. Respondents reported that the majority of abnormal coagulation studies they had ordered in the preceding 5 years were flagged and that normal reference ranges were provided; however, they reported little familiarity with 1:1 mixing studies, tests that would be routinely performed to determine whether a prolonged PT or aPTT was the result of a factor deficiency (adding normal plasma corrects the PT/aPTT) or an inhibitor (adding normal plasma does not correct the PT/aPTT).22 Furthermore, in contrast to coagulation studies, on-site mixing studies were not known to be widely available for the survey participants; only 22% reported that mixing studies were performed at their respective practice locations.

Similar high percentages of participants in the global and US surveys (58% and 52%, respectively) reported having discovered an underlying bleeding disorder in a patient with PPH. Incidence of massive PPH resulting in coagulopathy (acquired or congenital) is reported to be between 0.15% and 0.5%,4,2325 with massive blood loss due to uterine atony being the most common cause (39%). The most common congenital bleeding disorder is VWD, with an estimated prevalence of up to 1% to 2% in the population; incidence of PPH in women with VWD is 1.5 times higher than in controls (6% vs 4%) and transfusion is 4.7 times more likely.26 Thus, it might be expected that most obstetricians experienced with PPH related to underlying bleeding disorders will have experience with common congenital and acquired disorders. In contrast, a higher percentage had encountered the rare disorder of acquired hemophilia than might be expected, and also in comparison with the corresponding subset of participants in the US survey (23% and 4%, respectively). However, self-reported knowledge of acquired hemophilia was low, with 80% of the overall global sample reporting that they knew little or nothing about this rare (~1 in 1–1.5 million) condition characterized by autoantibodies to factor VIII in older adults and postpartum women (up to 6 to 12 months post-delivery).27

Higher percentages of respondents overall, and in most countries in the global survey, had consulted a hematologist compared with those in the US survey, although the greatest percentage had done so only once or twice in their careers. An exception to the low rates of hematology consultation was the UK cohort practicing under a national health system with centralized hematology laboratory services; the majority of UK respondents had consulted a hematologist 5 or more times for PPH. Nearly one-quarter of participants overall had never consulted a hematologist for a patient with PPH.

A limitation of this survey was that it did not assess potential systemic differences across countries that may have influenced participants’ responses. Additional potential limitations include the elective nature of participation (those with an interest in coagulation studies may have been more likely to respond) and small sample sizes within individual countries.

Nonetheless, these data highlight opportunities for improving awareness of how to rapidly and efficiently identify coagulation disorders among women with PPH. Greater consistency in approaches towards performing and interpreting basic laboratory assessments (PT/aPTT), as well as deciding when to consult with a hematologist, may encourage greater focus on identifying the underlying causes of severe PPH.


Confirming and expanding upon the findings of the similar US survey, the results of this quantitative global survey of obstetrician-gynecologists across different health care delivery systems revealed potential barriers to identifying congenital and acquired bleeding disorders as a contributing factor in PPH. Potential barriers include the lack of a consensus definition for massive PPH, inconsistent ordering and interpretation of basic coagulation studies (PT/aPTT), limited availability of follow-up laboratory tests (mixing studies, factor assays, inhibitor tests), lack of experience with and knowledge of bleeding disorders, and infrequent involvement of a hematologist in the care of patients with PPH. Addressing such barriers in local practice protocols and in national consensus guidelines may serve to facilitate prompt identification of both common and uncommon contributing acquired or congenital bleeding disorders in patients with PPH and provide valuable information for ensuring appropriate therapeutic management.


The quantitative and qualitative research surveys described in this manuscript were completed by Harris Interactive, New York, NY, USA, with funding provided by Novo Nordisk Healthcare AG., Zurich, Switzerland. Editorial assistance was provided by Anna Abt, PhD, of ETHOS Health Communications in Yardley, PA, USA, with financial support from Novo Nordisk Inc., in compliance with international guidelines for Good Publication Practice.


David L Cooper is an employee of Novo Nordisk Inc. Andra H James and Michael J Paidas report no conflicts of interest in this work.



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