A comparison of methodologies for the real-time identification of hospitalized patients with acute exacerbations of COPD
Received 25 May 2018
Accepted for publication 1 February 2019
Published 22 March 2019 Volume 2019:14 Pages 693—698
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Amy Norman
Peer reviewer comments 4
Editor who approved publication: Dr Richard Russell
Parth Shah,1 Andrew McWilliams,2 Daniel Howard,3 Jason Roberge4
1UNC School of Medicine, Center for Outcomes Research and Evaluation, Atrium Health, Charlotte, NC 28203, USA; 2Carolinas Hospitalist Group, Center for Outcomes Research and Evaluation, Atrium Health, Charlotte, NC 28203, USA; 3Medical Group Division, Atrium Health, Charlotte, NC 28232, USA; 4Center for Outcomes Research and Evaluation, Atrium Health, Charlotte, NC 28203, USA
Background: COPD is a lung disease characterized by chronic, irreversible airway obstruction that can precipitate into acute exacerbations of COPD (AECOPD) often requiring hospitalization. Improving these outcomes will require proactive innovations in care delivery to at-risk populations. Data-driven models to identify patients with AECOPD on admission to the hospital are needed, but do not exist.
Objective: This study aimed to compare the performance of several models designed to identify patients with AECOPD within 24 hours of hospital admission.
Methods: Clinical factors associated with admissions for AECOPD that are available within 24 hours of an encounter were combined into six different models and then tested retrospectively to evaluate each model’s performance in predicting AECOPD. The data set incorporated billing and clinical data from patients who were older than 40 years of age with an inpatient or observation encounter in 2016 at one of the nine hospitals within a large integrated healthcare system.
Results: Of the 116,329 encounters, 6,383 had a billing diagnosis for AECOPD. The models showed a wide range of sensitivity (0.473 vs 0.963) and positive predictive value (0.190 vs 0.827).
Conclusion: It is possible to leverage clinical and administrative data to identify patients admitted with AECOPD in real-time for quality improvement or research purposes. Because models relied on clinical data, local variation in care delivery also likely contributed to performance variation across hospitals. These findings emphasize the importance of testing model performance on local data and choosing the model that best aligns with the specific goals of the targeted initiative.
Keywords: quality improvement, outcomes research, AECOPD, model, validity
This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.Download Article [PDF] View Full Text [HTML][Machine readable]