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A comparative study of the five-repetition sit-to-stand test and the 30-second sit-to-stand test to assess exercise tolerance in COPD patients

Authors Zhang Q, Li YX, Li XL, Yin Y, Li RL, Qiao X, Li W, Ma HF, Ma WH, Han YF, Zeng GQ, Wang QY, Kang J, Hou G

Received 8 May 2018

Accepted for publication 25 July 2018

Published 10 September 2018 Volume 2018:13 Pages 2833—2839

DOI https://doi.org/10.2147/COPD.S173509

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 3

Editor who approved publication: Professor Chunxue Bai


Qin Zhang,1 Yan-xia Li,2 Xue-lian Li,3 Yan Yin,1 Rui-lan Li,1 Xin Qiao,1 Wei Li,1 Hai-feng Ma,1 Wen-hui Ma,1 Yu-feng Han,1 Guang-qiao Zeng,4 Qiu-yue Wang,1 Jian Kang,1 Gang Hou1

1Institute of Respiratory Disease, First Hospital of China Medical University, Shenyang, China; 2Department of Respiratory Medicine, First Hospital of Dalian Medical University, Dalian, China; 3Department of Epidemiology, School of Public Health, China Medical University, Shenyang, China; 4State Key Laboratory of Respiratory Disease, National Clinical Research Center of Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China

Purpose: The sit-to-stand test (STST) has been used to evaluate the exercise tolerance of patients with COPD. However, mutual comparisons to predict poor exercise tolerance have been hindered by the variety of STST modes used in previous studies, which also did not consider patients’ subjective perceptions of different STST modes. Our aim was to compare the five-repetition sit-to-stand test (5STS) with the 30-second sit-to-stand test (30STS) for predicting poor performance in the six-minute walking test and to evaluate patients’ subjective perceptions to determine the optimal mode for clinical practice.
Patients and methods: Patients with stable COPD performed 5STS, 30STS and the 6MWT and then evaluated their feelings about the two STST modes by Borg dyspnea score and a questionnaire. Moreover, we collected data through the pulmonary function test, mMRC dyspnea score, COPD assessment test and quadriceps muscle strength (QMS). A receiver operating characteristic curve analysis of the 5STS and 30STS results was used to predict 6-minute walk distance (6MWD) <350 m.
Results: The final analysis included 128 patients. Similar moderate correlations were observed between 6MWT and 5STS (r=-0.508, P<0.001) and between 6MWT and 30STS (r=0.528, P<0.001), and there were similar correlations between QMS and 5STS (r=-0.401, P<0.001) and between QMS and 30STS (r=0.398, P<0.001). The 5STS and 30STS score cutoffs produced sensitivity, specificity and positive and negative predictive values of 76.0%, 62.8%, 56.7% and 80.3% (5STS) and 62.0%, 75.0%, 62.0% and 75.0% (30STS), respectively, for predicting poor 6MWT performance. The 5STS exhibited obvious superiority in terms of the completion rate and the subjective feelings of the participants.
Conclusion: As a primary screening test for predicting poor 6MWD, the 5STS is similar to the 30STS in terms of sensitivity and specificity, but the 5STS has a better patient experience.

Keywords: sit-to-stand test, six-minute walk test, COPD, exercise endurance

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