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A case of orbital sebaceous gland carcinoma developing in an anophthalmic socket 65 years after enucleation

Authors Shibata M, Usui Y, Ueda S, Matsumura H, Nagao T, Goto H

Received 1 March 2013

Accepted for publication 2 April 2013

Published 16 September 2013 Volume 2013:7 Pages 1825—1827

DOI https://doi.org/10.2147/OPTH.S44639

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Motoko Shibata,1,* Yoshihiko Usui,1,* Shunichiro Ueda,1 Hajime Matsumura,2 Toshitaka Nagao,3 Hiroshi Goto1

1Department of Ophthalmology, 2Department of Plastic and Reconstructive Surgery, 3Department of Anatomic Pathology, Tokyo Medical University, Tokyo, Japan

*These authors contributed equally to this work

Abstract: Although conjunctival squamous cell carcinoma is known to develop as a result of chronic irritation from wearing an ocular prosthesis, orbital sebaceous gland carcinoma arising in an anophthalmic pocket is extremely rare. We report a 68-year-old female who developed a sebaceous gland carcinoma 65 years after her right eye was enucleated (at the age of three years) due to congenital glaucoma. The patient had noticed increasing discharge and swelling of her right eyelid. Incisional biopsies of an underlying orbital mass revealed poorly differentiated sebaceous gland carcinoma. The sebaceous gland carcinoma in this case could have been caused by chronic irritation as a result of long-standing use of a poorly fitted ocular prosthesis. The current case of a malignant tumor occurring 65 years after enucleation emphasizes the importance of long-term clinical surveillance to monitor for tumor formation. Careful examination of the anophthalmic socket should be part of the physical examination.

Keywords: sebaceous gland carcinoma, anophthalmos, orbit

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