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99mTc-labeled sodium phytate and stannous chloride injection accurately detects sentinel lymph node in axillary of early stage breast cancer: a randomized, controlled study

Authors Yang S, Bao W, Bai X, Gao C, Zhang B, Jiang Z

Received 26 October 2017

Accepted for publication 4 January 2018

Published 4 April 2018 Volume 2018:11 Pages 1891—1898

DOI https://doi.org/10.2147/OTT.S155265

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Prof. Dr. Geoffrey Pietersz


Suisheng Yang,* Weiyu Bao,* Xiaorong Bai, Chen Gao, Binming Zhang, Zhuanji Jiang

Department of Breast Surgery, Gansu Provincial Cancer Hospital, Lanzhou, China

*These authors contributed equally to this work

Aim: The aim of this study was to assess the sentinel lymph node (SLN) detection rate and accuracy of 99mTc-labeled sodium phytate and stannous chloride (99mTc-PHY) injection versus 99mTc-labeled sulfur colloid (99mTc-SC) injection in sentinel lymph node biopsy (SLNB) in patients with early stage breast cancer.
Methods: A total of 146 consecutive female patients with early stage breast cancer were recruited in this open-labeled, randomized, controlled study. SLNB was conducted on all patients, and 99mTc-PHY or 99mTc-SC was used as the radioactive agent (RA). Axillary lymph node dissections were performed in all patients post SLN dissections.
Results: The detection rate of 99mTc-PHY group was higher compared with that of 99mTc-SC group (p=0.023), but no difference in the detection rate by dye alone (p=0.190) or by RAs alone (p=0.615) was found between the two groups, and the number of identified SLNs (p=0.100), number of identified SLNs by dye alone (p=0.161), and number of identified SLNs by RA alone (p=0.242) were similar between the two groups. In addition, the sensitivity, specificity, false-negative rate, false-positive rate, and accuracy rate of SLNB showed no difference between 99mTc-PHY and 99mTc-SC groups (sensitivity: p=0.645; specificity: p=0.511; false-negative rate: p=0.645; false-positive rate: p=0.511; accuracy rate: p=0.464).
Conclusion:
Our study revealed that 99mTc-PHY was qualified to be a convincing radiopharmaceutical in SLNB.

Keywords: breast cancer, sentinel lymph node biopsy, 99mTc, sodium phytate, stannous chloride, detection rate

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