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Yellow Nail Syndrome Successfully Treated with Oral Terbinafine and Topical Minoxidil

Authors Algain M

Received 14 January 2021

Accepted for publication 23 February 2021

Published 12 March 2021 Volume 2021:14 Pages 249—252

DOI https://doi.org/10.2147/CCID.S301197

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Jeffrey Weinberg


Maysoon Algain

Department of Dermatology, King Abdulaziz University, Jeddah, Saudi Arabia

Correspondence: Maysoon Algain Department of Dermatology
King Abdulaziz University, Jeddah, Saudi Arabia
Tel +966 503000301
Email [email protected]

Abstract: Yellow nail syndrome (YNS) is a rare disease of unknown etiology that is characterized by varying degrees of pulmonary manifestations, lymphedema, and yellow discoloration of the nails. Herein, we report the efficacy of oral terbinafine and topical minoxidil in treating the associated nail abnormalities of YNS in a 66-year-old woman. The patient presented with yellow, brittle, slow-growing nails, which had developed progressively over the past 8 months; left ankle edema; a chronic, purulent, productive cough; and exertional dyspnea. Based on these symptoms, she was diagnosed with YNS. She failed to respond to treatment with fluconazole and vitamin E; however, she was successfully treated with oral terbinafine and topical minoxidil. The treatment was well tolerated, and we speculate that its mode of action includes promoting lymphatic formation and barrier enhancement, thereby improving the distal lymphedema, in addition to distal vasodilation that accelerates the nail growth. To our knowledge, this is the first report of successful treatment of YNS using these agents.

Keywords: exertional dyspnea, lymphedema, productive cough, case report

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