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Vitamin D reduces falls and hip fractures in vascular Parkinsonism but not in Parkinson’s disease

Authors Sato Y, Iwamoto J, Honda Y, Amano N

Received 8 February 2013

Accepted for publication 15 March 2013

Published 22 April 2013 Volume 2013:9 Pages 171—176


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

This paper has been retracted.

Yoshihiro Sato,1 Jun Iwamoto,2 Yoshiaki Honda,1 Nobuko Amano3

1Department of Neurology, Mitate Hospital, Tagawa, Japan; 2Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, Japan; 3Department of Food and Nutrition, Tezukayama University, Nara, Japan

Purpose: Vitamin D supplementation is suggested to reduce the risk of falls in older institutionalized or ambulatory individuals by 20%. The present study was undertaken to address the reduced risk, by vitamin D supplementation, of falls and hip fractures in patients with vascular Parkinsonism (VP) and Parkinson’s disease (PD).
Patients and methods: In the open-label-study, 94 elderly patients with VP and 92 age-matched patients with PD were followed for 2 years. All patients received 1200 IU ergocalciferol daily. The number of falls per person and incidence of hip fractures were compared between the two groups.
Results: At baseline, serum 25-hydroxyvitamin D (25-OHD) levels were in the deficient range (P < 0.001). Hip fractures occurred in seven of 88 in the PD group and one in 90 of the VP group during the 2-year study period (P = 0.035).
Conclusion: It is suggested that vitamin D decreases falls and hip fractures in VP by increasing muscle strength but not in PD.

Keywords: fall, hip fracture, Parkinson’s disease, vascular Parkinsonism, vitamin D

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