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Use of levosimendan in acute and advanced heart failure: short review on available real-world data

Authors Pashkovetsky E, Gupta CA, Aronow WS

Received 20 March 2019

Accepted for publication 1 June 2019

Published 17 June 2019 Volume 2019:15 Pages 765—772

DOI https://doi.org/10.2147/TCRM.S188761

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Melinda Thomas

Peer reviewer comments 2

Editor who approved publication: Professor Garry Walsh


Eugene Pashkovetsky, Chhaya Aggarwal Gupta, Wilbert S Aronow

Division of Cardiology, Department of Medicine, Westchester Medical Center and New York Medical College, Valhalla, NY 10595, USA

Abstract: Published data have shown potential advantages of levosimendan in the management of acute decompensated heart failure and advanced heart failure when standard medical therapies threaten hemodynamics and organ perfusion are unable to alleviate clinical symptoms. Levosimendan distinguishes itself from other catecholaminergic inotropes by its three mechanisms of action: positive inotropy, vasodilation, and cardioprotection. In addition, its pharmacokinetics allow for a longer duration of action from the metabolite OR1896 allowing for further cardiovascular therapeutic effects for several days, even after discontinuation of the parent drug.

Keywords: levosimendan, heart failure, inotropic therapy



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