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Uric Acid and Arterial Stiffness

Authors Albu A, Para I, Porojan M

Received 22 September 2019

Accepted for publication 1 December 2019

Published 28 January 2020 Volume 2020:16 Pages 39—54

DOI https://doi.org/10.2147/TCRM.S232033

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Professor Garry Walsh


Adriana Albu,1 Ioana Para,2 Mihai Porojan1

12nd Department of Internal Medicine; 24th Department of Internal Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania

Correspondence: Ioana Para
4th Department of Internal Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, 8 Babes Street, Cluj-Napoca 400012, Romania
Email ioana.para@yahoo.com

Abstract: Hyperuricemia is usually associated with hypertension, diabetes mellitus, metabolic syndrome and chronic kidney disease. Accumulating data from epidemiological studies indicate an association of increased uric acid (UA) with cardiovascular diseases. Possible pathogenic mechanisms include enhancement of oxidative stress and systemic inflammation caused by hyperuricemia. Arterial stiffness may be one of the possible pathways between hyperuricemia and cardiovascular disease, but a clear relationship between increased UA and vascular alterations has not been confirmed. The review summarizes the epidemiological studies investigating the relationship between UA and arterial stiffness and highlights the results of interventional studies evaluating arterial stiffness parameters in patients treated with UA-lowering drugs.

Keywords: uric acid, arterial stiffness, cardiovascular risk

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