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Update on neuromyelitis optica: natural history and management

Authors Jindahra P, Plant G

Received 15 October 2011

Accepted for publication 4 January 2012

Published 28 March 2012 Volume 2012:4 Pages 27—41

DOI https://doi.org/10.2147/EB.S8392

Review by Single-blind

Peer reviewer comments 3


Panitha Jindahra1,2, Gordon T Plant1,2
1The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK; 2St Thomas' Hospital, Westminster Bridge Road, London, UK

Abstract: Neuromyelitis optica or Devic disease is an inflammatory disorder of the central nervous system. It is caused by antibodies that attack aquaporin 4 water channels in the cell membrane of astrocytic foot processes at the blood brain barrier. It can involve the optic nerve, the spinal cord and beyond. Here we review its pathophysiology, clinical features, and therapy.

Keywords: Neuromyelitis optica, Devic disease, NMO-IgG, optic neuritis, transverse myelitis, NMO spectrum disorders

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