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Understanding Patient Perspectives and Awareness of the Impact and Treatment of Anemia with Chronic Kidney Disease: A Patient Survey in China

Authors Hao CM, Wittbrodt ET, Palaka E, Guzman N, Dunn A, Grandy S

Received 10 November 2020

Accepted for publication 20 January 2021

Published 22 February 2021 Volume 2021:14 Pages 53—64


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Professor Pravin Singhal

Chuan-Ming Hao,1 Eric T Wittbrodt,2 Eirini Palaka,3 Nicolas Guzman,4 Alicia Dunn,5 Susan Grandy6

1Fudan University, Huashan Hospital, Shanghai, People’s Republic of China; 2Biopharmaceuticals Medical Unit, AstraZeneca, Gaithersburg, MD, USA; 3Biopharmaceuticals Global Market Access, AstraZeneca, Cambridge, UK; 4Global Medicines Development, AstraZeneca, Gaithersburg, MD, USA; 5AstraZeneca Global Corporate Affairs Gaithersburg, Gaithersburg, MD, USA; 6Biopharmaceuticals Global Market Access, AstraZeneca, Gaithersburg, MD, USA

Correspondence: Chuan-Ming Hao
Fudan University, Huashan Hospital, Shanghai, People’s Republic of China
Tel +86-21-62480303

Background: Anemia is a common complication of chronic kidney disease (CKD) that may reduce patients’ health-related quality of life (HRQoL). This study explored the experience and knowledge of patients with CKD, with and without anemia, in China.
Methods: A quantitative online survey was administered to 500 consenting Chinese patient volunteers aged ≥ 18 years with self-reported CKD, with or without anemia, between August 29, and September 17, 2018. Patients with cancer were excluded. The 27-question survey explored knowledge of anemia, HRQoL, anemia management, and interactions with healthcare providers.
Results: Of 456 evaluable patients, 148 (32.5%) reported having anemia and 262 (57.5%) did not. Knowledge of anemia and its symptoms varied, and approximately half of all patients did not know their hemoglobin level. Patients with anemia expressed an adverse impact of anemia on HRQoL, most commonly lack of energy (65.5%), sadness/depression (54.1%), and feeling ill (50.0%). The most frequently reported treatments among these patients were dietary advice (68.9%), iron supplements (63.5%), and oral medications (53.4%). Although 89.2% of patients with anemia trusted their healthcare providers above other information sources, only 29.0% reported seeking information from them; this was despite 92.6% reporting wanting further information and support about managing conditions like anemia.
Conclusion: Our findings suggest that patients with CKD, both with and without anemia, would benefit from increased awareness of anemia and more in-depth discussions with healthcare providers in order to facilitate better management of CKD and optimization of treatment plans.

Keywords: anemia, chronic kidney disease, survey, patient perspectives, China


Chronic kidney disease (CKD) is a growing health concern, both in China and the rest of the world.1,2 In a report published in 2018, there was an estimated CKD prevalence of 11.6% in the overall population of China.1 This figure is expected to increase in the future, given contributing factors such as continued changes in diet and lifestyle, an aging population2–4 and, potentially, increased disease recognition by physicians. The main cause of CKD in China is glomerulonephritis, but this may be supplanted by diabetes and hypertension in coming years as the prevalence of these conditions increases among the Chinese population.4

Anemia becomes increasingly prevalent among patients with CKD as the disease progresses, and affects almost all patients eligible for dialysis.5,6 In China, approximately half of patients with CKD not on dialysis and nearly 70% of those with diabetic nephropathy are affected by anemia.7 A 2015 analysis estimated the age-adjusted incidence of dialysis-dependent CKD to be 122.19 per million in China.8 There are well-established serious consequences associated with anemia in CKD, including CKD progression, cardiovascular disease, and increased mortality risk.6,9–11 The presence of anemia with CKD is also associated with reduced health-related quality of life (HRQoL).12

Although treatments exist for anemia in CKD, current evidence suggests that the condition is under-recognized and undertreated in clinical practice.7,13,14 This is partly because patients with early-stage CKD often show only mild or no visible symptoms, therefore the disease is frequently not diagnosed until it has reached an advanced stage, where the risks of morbidity and mortality are significantly higher than at earlier stages.15,16 As medical care and innovative treatment options become increasingly available in China, understanding of CKD and its management are improving;17 however, published data specific to Chinese patients are scarce.

Patient insights specific to the Chinese population are important for understanding how to address the critical unmet needs of patients living with a disease or condition in China. Patients’ participation in healthcare and treatment can help providers understand and consider patients’ opinions and experiences, also known as the “patient voice”, which may lead to improved health outcomes and increased satisfaction with healthcare.18 Patient insights can also provide information about how actively patients are involved in their own care, which is recognized as a key component of chronic disease management.19 In general, information about the experience of patients with CKD is lacking, particularly from patients without end-stage renal disease (ESRD).20,21

This study aimed to understand the experience of patients with CKD and anemia in China by means of an online survey, focusing specifically on the prevalence of anemia, knowledge about anemia, HRQoL, how the condition is treated and managed, and patients’ perspectives on healthcare practitioner–patient relationships.


Survey Design and Participants

A quantitative online survey, developed in collaboration with Portland Communications (London, UK), was completed by 500 Chinese patient volunteers between August 29 and September 17, 2018. All patients invited to complete the survey had provided informed consent, were aged ≥18 years, and had self-reported CKD of any stage, with or without anemia. Patients were recruited from an online community, patient associations, online support groups, and from patient referrals by the research firm, Opinion Health Ltd (London, UK), according to their standard recruitment protocol. In brief, a random sample of potential patients were invited to participate in the online survey, and response rates were monitored. Additional patients were invited in order to ensure a balanced sample composition in terms of gender, age, geographic region, and other sociodemographic characteristics. Recruitment was not subject to quotas for CKD disease stages or dialysis status.

Portland Communications worked with Opinion Health to carry out recruitment, field work, and data processing. The research was carried out in accordance with the European Pharmaceutical Market Research Association Code of Conduct, European Medicines Agency good pharmacovigilance practice guidelines, and General Data Protection Regulation guidance. All patients provided completed online consent forms to take part in the study and were financially compensated for their time.

Data Collection

The 27-question survey was developed de novo for the present study and was made available on an online platform through a weblink sent directly to the email address of each recruited participant. The survey questions were translated to both Mandarin and Cantonese by an ISO-certified translation company for the purpose of this study, with all translations subject to quality assurance checks. Prior to completing the survey questions, participants were required to complete three initial screening questions to confirm that they had CKD, and to report any comorbidities and CKD stage. In particular, patients were asked whether they had cancer or cancer-induced anemia, to avoid confounding the etiology of anemia if both CKD and cancer were present. Demographic questions were also asked regarding gender, age, and region.

The main part of the survey explored patients’ knowledge of anemia, whether they had been diagnosed with anemia by a doctor (no definition of anemia was provided; patients were asked to report their hemoglobin level if they had received a blood test in the past year, but this information was not mandatory), information sources used to learn about the condition, disease management by healthcare practitioners, and relationships between patients and their healthcare practitioners. Some questions were asked only to patients who reported having been diagnosed with anemia, including questions about the impact of anemia on HRQoL and on the management of anemia by healthcare practitioners. The full list of survey questions is provided in the Supplementary Material. Patients were required to complete all survey questions. All information on disease status was self-reported by patients, including CKD stage, presence of anemia, and treatments received; responses were not further validated clinically. Data collected from the survey were aggregated and anonymized to protect patient confidentiality.

Statistical Analysis

The findings are reported descriptively as figures, which include n (%) of patients for each response. No hypotheses were tested, and no inferential statistics were performed.


Of 500 volunteers who completed the survey, 44 patients reported having cancer or cancer-induced anemia and were not included in the overall analytic cohort.

Baseline Characteristics

Baseline characteristics of the 456 survey respondents included in the overall analytic cohort are presented in Table 1. Overall, 148 patients (32.5%) reported being diagnosed with anemia, and 262 (57.5%) reported not being diagnosed with anemia. In total, 46 patients were unaware of their anemia status and were not included in either the anemia or non-anemia cohorts. Among patients with self-reported anemia, almost two-thirds were between 36 and 50 years old, and 61.5% were male. The non-anemia cohort had a greater proportion of older patients (aged 51–65 years) compared with the anemia cohort (16.8% vs 2.7%), but patients in the non-anemia cohort were less likely to have a comorbidity (34.4% vs 74.3%), which was true for all of the individual conditions listed (Table 1). The most frequently reported comorbidities among patients with anemia were hypertension (36.5%) and type 2 diabetes/high blood glucose (24.3%).

Table 1 Baseline Characteristics, as Self-Reported by Patients

In the overall analytic cohort, the proportions of patients with stage 1, 2, and 3 CKD were 39.0%, 34.4%, and 16.7%, respectively, with the remainder having stage 4 or 5 CKD (6.6%) or being unaware of their disease stage (3.3%). Most patients without anemia (81.3%) had stage 1 or 2 CKD, and only 7.6% had stage 3 CKD. By contrast, the proportions of patients with self-reported anemia who had stage 1 or 2 CKD vs stage 3 CKD were 57.4% and 37.2%, respectively.

In the anemia cohort, only 56.8% reported being treated for both CKD and anemia, and 41.2% reported being treated just for CKD. In the non-anemia cohort, 23.7% reported that they were not receiving any treatment for CKD, and 6.9% reported that they were being treated for both CKD and anemia (Table 1), despite having previously reported that they had not been diagnosed with anemia by a doctor.


Most patients with self-reported anemia (87.2%) had been informed about the association between CKD and anemia by their doctor. However, 46.6% of these patients reported not knowing their hemoglobin (Hb) level, and 9.5% reported not having had a blood test in the previous year. Among non-anemic patients, 53.1% reported being unaware of their Hb level, and 26.3% said that they had not undergone a blood test in the past year (Figure 1).

Figure 1 Knowledge of hemoglobin levels.Notes: Charts show the percentages of patients who selected each response to the question, “If you’ve had a blood test in the past year, do you know what your hemoglobin level is?”.

Among patients who knew their Hb level in the overall cohort (n=125), 42 of 73 (57.5%) men reported levels below the standard anemia definition threshold of 13.0 g/dL for men, and 16 of 52 (30.8%) women reported levels below the threshold of 12.0 g/dL for women (Supplementary Table 1). A breakdown of Hb levels was not available for the anemia and non-anemia cohorts separately, so it is unclear whether this difference between men and women is driven by differences in the numbers of anemic men and women with available Hb levels. Within the anemia cohort, 32 of 65 (49.2%) patients reported Hb levels under 12.0 g/dL, and eight of 54 (14.8%) of the non-anemic patients reported Hb levels below this threshold.

When asked whether statements relating to the causes of anemia were true or false, understanding of the causes of anemia was, in general, slightly higher among anemic than non-anemic patients. However, a higher proportion of non-anemic patients knew that anemia could be treated (30.2% vs 24.3%; Figure 2). There were also some misconceptions about the causes of anemia in both cohorts, with approximately one-third of both anemic and non-anemic patients believing that anemia is caused by low blood sugar. Patients’ knowledge of the symptoms of anemia appeared to vary between the cohorts with and without anemia (Figure 3). The biggest numeric difference was the belief that chest pain is a symptom of anemia, reported by 20.9% of anemic patients vs 5.3% of non-anemic patients.

Figure 2 Beliefs about anemia and its causes.Notes: Graph shows the percentages of patients who selected each statement in response to the question, “Which of the following statements about anemia do you think are correct?”.

Figure 3 Beliefs about the symptoms of anemia.Notes: Graph shows the percentages of patients who selected each statement in response to the question, “Which of the following do you think are symptoms of anemia?”.

Knowledge of available anemia treatment options also varied considerably between the anemia and non-anemia cohorts (Figure 4). Among the anemia cohort, 85.8% of patients reported that they were made aware of available treatment options by their doctor, who either informed them proactively (52.7%) or responded to their request for information (33.1%). The corresponding percentages were lower (22.5% and 24.4%) in non-anemic patients, but many said they would like to know more about anemia treatment options (30.2%). More patients in the anemia cohort reported feeling confident about their knowledge of the side effects of anemia treatments than in the non-anemia cohort (78.4% vs 38.5%).

Figure 4 Knowledge of anemia treatment options.Notes: Graph shows the percentages of patients who responded to the question, “Do you know about the different treatments that are available for managing anemia and, if so, how did you find out?”.

HRQoL in the Anemia Cohort

Patients with anemia reported that anemia worsened their feelings of lethargy and illness (Figure 5). The physical symptoms most impacted by anemia were lack of energy (65.5%) and feeling ill (50.0%; Figure 5A). Patients also attributed an emotional impact to anemia, particularly on sadness/depression (54.1%), nervousness (48.0%), and concern about their condition worsening (37.2%; Figure 5B).

Figure 5 Physical (A) and emotional (B) HRQoL (anemia cohort, n=148).Notes: Graphs show the percentages of patients who selected each response to the question when presented with a list of statements that are commonly reported by patients with chronic conditions. Arrow length indicates the percentage of patients who stated that a particular activity or feeling was made worse by their anemia. HRQoL, health-related quality of life.

Disease Management in the Anemia Cohort

When asked about how their doctor was currently managing their anemia, patients reported receiving a variety of therapies, most commonly dietary advice (68.9%), iron supplements (63.5%), and oral medications (53.4%; Figure 6A). Almost one-third of patients (31.1%) reported receiving blood transfusions.

Figure 6 Patient-reported treatments received for anemiaa (A) and patient perceptions of anemia managementb (B) (anemia cohort, n=148). aPercentage of patients who responded to the question, “How is your doctor managing your anemia?” bPercentage of patients who selected each response to the question, “On a scale from 1 to 5, how well do you think your anemia is managed, with 1 being ’very badly managed’, 3 being ‘neither badly nor well managed’, and 5 being ‘very well managed’?”.

Over 70.0% of patients diagnosed with anemia thought that their anemia was managed either well or very well by healthcare providers, while approximately one-quarter reported that their anemia was neither badly nor well managed. Less than 5% of patients reported that their anemia was either badly or very badly managed (Figure 6B). During regular check-ups, 65.5% of patients with anemia reported always being asked about their anemia symptoms, and 58.1% reported always having their Hb levels tested.

In total, 89.2% of patients with anemia trusted their healthcare providers above other information sources, despite using other sources more frequently to look for information about anemia (Figure 7A). The majority (92.6%) of patients stated that they would like more support and information about managing their condition.

Figure 7 Information sources and level of trust (A) and feelings after conversions with healthcare providers (B) (anemia cohort, n=148). aIncludes nephrologist, hematologist, cardiologist, another specialist, family doctor, nurse/clinic staff, or pharmacist. bAverage percentage of patients who rated their level of trust in the information sources as either a 5 or 4 on a scale of 1–5, where 5 is “completely” and 1 is “not at all”.

After speaking with their doctor, 45.9% of patients felt more confident about managing their anemia, and 60.8% of patients felt more knowledgeable; however, almost 30.0% of patients felt more scared about their anemia than before (Figure 7B).


To our knowledge, the present study is the first of its kind to explore the effects of anemia in CKD on HRQoL in Chinese patients. This survey of adults with CKD in China identified varying levels of disease-specific knowledge among patients with self-reported anemia, as well as a substantial perceived burden of anemia on the HRQoL of patients participating in this survey. Patients valued interactions with their healthcare providers, indicating an opportunity to increase and strengthen the dialogue between healthcare providers and patients.

Patient Characteristics, Knowledge of Anemia, and Disease Management

Consistent with previous studies,14,22 the prevalence of comorbidities, including diabetes, hypertension, and cardiovascular conditions, was higher in the anemic cohort than in the non-anemic cohort and more anemic patients had stage 3–5 CKD. Males were disproportionately represented in the anemia cohort compared with the overall cohort, despite data suggesting that women with CKD are more at risk of anemia than men.22,23

Approximately one-third of patients with CKD surveyed reported being diagnosed with anemia, yet over half of these patients did not know their most recent Hb level and/or had not had a blood test in the previous year. In fact, one-third of anemic patients said they were never or not always asked about their anemia symptoms during regular check-ups, and over 40% did not undergo regular blood testing to check their Hb level. These findings appear contradictory to Kidney Disease: Improving Global Outcomes (KDIGO) guidelines for the treatment of CKD patients with anemia who are not being treated with an erythropoiesis-stimulating agent (ESA). The guidelines recommend Hb monitoring at least every 3 months in patients with stage 3–5 CKD not on dialysis and at least monthly in patients with stage 5 CKD on hemodialysis.24 However, it should be noted that more than half of patients in the anemia cohort had stage 1 or 2 CKD, which may explain why their Hb levels were not being monitored this regularly. Additionally, some patients responding to the survey might have been unaware that Hb was being measured when undergoing blood testing; for example, if their physicians did not discuss the tests or results with them. Nevertheless, the high prevalence of anemia in the present cohort suggests a possible need for more frequent monitoring of Hb levels and better implementation of guidelines for anemia management.

Among patients in the overall cohort who knew their Hb levels, nearly one-third of women and over one-half of men were below current threshold levels for a diagnosis of anemia (13.0 g/dL for men and 12.0 g/dL for women, as per KDIGO guidelines).24 In the anemia and non-anemia cohorts, 49.2% and 14.8% of patients, respectively, had Hb levels below 12 g/dL, suggesting that there is variation in how patients perceive and define anemia. Additionally, 56.8% of the anemia cohort reported being treated for anemia in addition to CKD, but when asked specific questions about types of treatment 63.5% reported receiving iron supplements and 68.9% reported receiving dietary advice. This slight discrepancy suggests that some patients may have assumed a narrower definition of what constitutes anemia “treatment” than the options provided in the survey and/or perhaps did not consider “dietary advice” or over-the-counter iron to be “treatment”. The interrelated nature of CKD and anemia could also have contributed to patients being unclear as to which part of their disease was being addressed by their treatment.

The proportions of patients treated for anemia with injectable agents appear higher than figures for ESA and intravenous iron use reported in a recently published analysis25 and what might be expected given the KDIGO recommended threshold for ESA treatment (Hb <10 g/dL).24 The relatively high proportion of patients receiving blood transfusions is also somewhat surprising, given recommendations to avoid these when possible.24

Although the majority of patients with CKD and anemia considered their anemia to be well or very well managed, almost 30% of patients felt that their anemia was either managed badly or neither badly nor well. Over 90% said that they would like more support and information about managing their condition, and information from healthcare providers was trusted more highly than information found online, even though a high proportion of patients both with and without anemia reported looking for information about anemia on the internet. These responses emphasize the high value that patients with CKD and anemia place on their interactions with healthcare providers, suggesting an eagerness to obtain more information during consultations. Increasing dialog and disease education about anemia during consultations may improve patients’ perceptions of their anemia management and might also help them self-manage their disease, which is a critical aspect of care for patients with chronic diseases.26

Impact of Anemia on HRQoL

Although knowledge of the causes and symptoms of anemia varied, it was clear that patients with self-reported anemia perceived anemia as having a considerable negative impact on their HRQoL. In particular, many patients reported having a lack of energy, feeling ill, and a negative impact of anemia on their emotional well-being, including increased feelings of sadness/depression, nervousness, and concern about their condition worsening.

These findings concur with those from studies of patients with more severe CKD than in the present study, which reported lower HRQoL among patients with anemia vs without anemia.6,12 One study reported worse HRQoL among patients with severe anemia (defined as Hb levels <10 g/dL), with even moderate anemia (defined as Hb 10–12 g/dL) associated with poorer HRQoL scores for some measures compared with Hb >12 g/dL.6,12

A recent review of the impact of anemia on HRQoL in patients with CKD supports the notion of a correlation between Hb levels and HRQoL.27 The authors of this review emphasized the impact of anemia on energy/vitality and physical functioning, and noted that increases in Hb levels with anemia treatments may significantly improve HRQoL in patients with CKD and anemia, with the greatest improvements in those whose Hb levels are increased to the 10–12 g/dL range.27 While the survey used in the present study was focused on patient perceptions rather than on achievement of treatment targets, such as Hb level, it is possible that inertia in treating anemia early in this population contributed to low HRQoL in those who were untreated.

It should be noted that the appropriate target Hb level in CKD remains undetermined, and KDIGO guidelines recommend individualization of therapy in patients with CKD not on dialysis who have Hb levels <10 g/dL. This recommendation is due to variability in individual responses to anemia, with some patients having improvements in HRQoL at lower Hb levels.24

There are no standardized means of measuring HRQoL in patients with CKD.27 Different assessment tools used in clinical studies have included the KDQOL-36, the Kidney Disease Questionnaire, the EQ-5D, sickness impact profile, and linear analogue self-assessment. As a result, measurement of HRQoL in patients with CKD is very difficult and may fail to capture the full impact of CKD and its complications on the daily lives of affected patients. It should also be acknowledged that this study did not control for differences in other factors that might impact HRQoL, such as socioeconomic status, between the anemia and non-anemia cohorts.

To our knowledge, studies reporting on HRQoL in patients with CKD and anemia in China are limited, potentially due to a lack of robust data sets. However, some studies have investigated the impact of chronic conditions, including anemia, in Chinese patients. For example, a large population-based survey conducted in Shaanxi Province, China, showed an adverse impact of chronic diseases on HRQoL,28 and findings from the China Health and Retirement Longitudinal Study suggested that both anemia and low Hb levels were independent risk factors for cognitive decline.29 A small number of other studies have reported on HRQoL in Asian CKD populations. One study carried out in Japanese hemodialysis patients showed that both mental and physical component scores of the KDQOL-36 survey were both approximately 1.6 points lower in patients with Hb levels <8 g/dL compared with those who had less severe anemia (Hb levels of 11–12 g/dL). Although the difference was not statistically significant for the mental component scores,30 these findings may suggest a detrimental impact of severe anemia on physical functioning. Similarly, a Malaysian study of propensity score-matched patients with type 2 diabetes and CKD, with or without anemia, showed that SF-36 Version 2 QoL scores were lower in anemic patients but, again, were not significantly different.31 A recent study in India also showed consistently lower EQ-5D index values for patients with diabetic kidney disease and concomitant anemia.32

The findings from the present study concur with these findings, as the majority of patients with CKD and anemia reported an effect of anemia in worsening indicators of both physical and emotional HRQoL.

Study Limitations

This was a cross-sectional study, therefore no longitudinal data on changes in patient responses over time were collected. Although the self-reported nature of the data collected provides valuable insights direct from patients into their experience of living with CKD, the responses collected were not clinically validated and, as noted previously, there is no standardized means of assessing HRQoL in patients with CKD, which may add a level of uncertainty to the results. In particular, data on anemia status and disease stage were not confirmed using test results, treatments received were not validated using medical records, and the etiology of anemia was not assessed. For this reason, the possibility that some patients had anemia caused by other diseases cannot be excluded. The finding that 119 patients knew what their most recent Hb level was also adds a level of uncertainty to findings pertaining to the relationship between anemia and HRQoL outcomes.

Patients completed the survey online without the support of a healthcare provider, which might have led to differences in how study questions were interpreted. For example, some patients without anemia reported receiving treatments for anemia, possibly due to associating non-specific dietary advice with anemia. Although patients were asked about how anemia impacted their physical and emotional experience of CKD, this was subjective, and the relative contribution of anemia and other CKD symptoms could not be determined with certainty. Additionally, although no questions were asked specifically about traditional Chinese medicines, such as herbal extracts, patients may have included these when reporting oral medication use.

The study findings should also be viewed in the context of the survey population: over 70% of patients had stage 1 or 2 CKD, and almost 90% were 50 years of age or younger. These demographics may not represent the overall population of patients with CKD in all regions of China. Moreover, the data may not provide a fully comprehensive picture of how patients with anemia are treated in China, as they may only represent a small sample of patients with CKD and anemia in China. Patients with early-stage CKD may differ in their disease knowledge and perceptions of the impact of anemia on HRQoL compared with patients with more advanced disease. Our findings may also be impacted by a sampling bias, whereby patients who agree to participate in these types of studies and who are actively involved in community activities may be more positive about their disease and/or care than average patients with CKD in China. The online nature of the survey may also mean that patients with a high level of education and/or computer literacy are more likely to participate than those who are less educated. Finally, the size of the anemia cohort in this study was relatively small and whilst our findings provide valuable information, further studies are warranted to further explore the experience of patients with CKD and anemia in China.


This study is among the first to provide insight into patient-specific knowledge, awareness, and perceptions of CKD and anemia in China. Findings from this study show that patients with CKD, with and without anemia, in China would benefit from increased awareness of anemia and more in-depth interactions with healthcare providers regarding anemia and its associated risks. These improvements might help patients to play a more active role in their care, to better manage their CKD and improve outcomes.

Data Sharing Statement

Data underlying the findings described in this manuscript may be obtained in accordance with AstraZeneca’s data sharing policy described at:


We thank the patients who participated in this study for their contributions to progressing the understanding of chronic kidney disease and its impact on patients’ lives. Medical writing support was provided by Lucy Ambrose, DPhil (Oxon), and editorial support was provided by Bethany King, both of Core Medica, London, UK, supported by AstraZeneca according to Good Publication Practice guidelines (Link).

Author Contributions

Study design and data collection: C.M. Hao, A. Dunn, E. Palaka, E.T. Wittbrodt, S. Grandy. All authors contributed to data analysis, drafting or revising the article, have agreed on the journal to which the article will be submitted, gave final approval of the version to be published, and agree to be accountable for all aspects of the work.


This study was funded by AstraZeneca. The sponsor was involved in the study design, collection, analysis, and interpretation of data, as well as data checking of information provided in the manuscript. However, ultimate responsibility for opinions, conclusions and data interpretation lies with the authors.


C.M. Hao has received honoraria from AstraZeneca and FibroGen. E.T. Wittbrodt, N. Guzman, A. Dunn, and S. Grandy are employees and stockholders of AstraZeneca. E. Palaka is a former employee and stockholder of AstraZeneca. The authors report no other conflicts of interest related to this work.


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