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Ultrafast sonochemical synthesis of protein-inorganic nanoflowers

Authors Batule BS, Park KS, Kim MI, Park HG, An SSA

Received 10 June 2015

Accepted for publication 28 July 2015

Published 25 August 2015 Volume 2015:10(Special Issue on diverse applications in Nano-Theranostics) Pages 137—142

DOI https://doi.org/10.2147/IJN.S90274

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Farooq Shiekh

Peer reviewer comments 3

Editor who approved publication: Prof. Dr. Thomas J Webster

Bhagwan S Batule,1 Ki Soo Park,1 Moon Il Kim,2 Hyun Gyu Park1

1Department of Chemical and Biomolecular Engineering (BK21+ Program), Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 2Department of BioNano Technology, Gachon University, Seongnam, Republic of Korea

Abstract: We developed a simple but efficient method to synthesize protein-inorganic hybrid nanostructures with a flower-like shape (nanoflowers), which relies on sonication to facilitate the synthesis of the nanoflowers. With this technique, we synthesized nanoflowers containing laccase as a model protein and copper phosphate within 5 minutes at room temperature. The resulting laccase nanoflowers yielded greatly enhanced activity, stability, and reusability, and their usefulness was successfully demonstrated by applying them in the colorimetric detection of epinephrine. The strategy developed could be used to rapidly synthesize nanoflowers for various applications in biosensor and enzyme catalysis and would expand the utilization of nanoflowers in diverse fields of biotechnology.

Keywords: copper phosphate, laccase, epinephrine, hybrid nanomaterials

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