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Trihydroxybenzoic acid glucoside as a global skin color modulator and photo-protectant

Authors Chajra H, Redziniak G, Auriol D, Schweikert K, Lefevre F

Received 29 July 2015

Accepted for publication 10 September 2015

Published 25 November 2015 Volume 2015:8 Pages 579—589


Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Ram Prasad

Peer reviewer comments 2

Editor who approved publication: Dr Jeffrey Weinberg

Hanane Chajra,1 Gérard Redziniak,2 Daniel Auriol,3 Kuno Schweikert,1 Fabrice Lefevre1

1Induchem AG, Volkestwil, Switzerland; 2Cosmetic Invention, Antony, 3Libragen SA, Toulouse, France

Background: 3,4,5-Trihydroxybenzoic acid glucoside (THBG), a molecule produced by an original biocatalysis-based technology, was assessed in this study with respect to its skin photoprotective capacity and its skin color control property on Asian-type skin at a clinical level and on skin explant culture models.
Methods: The double-blinded clinical study was done in comparison to a vehicle by the determination of objective color parameters thanks to recognized quantitative and qualitative analysis tools, including Chroma-Meter, VISIA-CR™, and SIAscope™. Determination of L* (brightness), a* and b* (green–red and blue–yellow chromaticity coordinates), individual typology angle, and C* (chroma) and h* (hue angle) parameters using a Chroma-Meter demonstrated that THBG is able to modify skin color while quantification of ultraviolet (UV) spots by VISIA-CR™ confirmed its photoprotective effect. The mechanism of action of THBG molecule was determined using explant skin culture model coupled to histological analysis (epidermis melanin content staining).
Results: We have demonstrated that THBG was able to modulate significantly several critical parameters involved in skin color control such as L* (brightness), a* (redness), individual typology angle (pigmentation), and hue angle (yellowness in this study), whereas no modification occurs on b* and C* parameters. We have demonstrated using histological staining that THBG decrease epidermis melanin content under unirradiated and irradiated condition. We also confirmed that THBG molecule is not a sunscreen agent.
Conclusion: This study demonstrated that THBG controls skin tone via the inhibition of melanin synthesis as well as the modulation of skin brightness, yellowness, and redness.

Keywords: skin color, UV spots, pigmentation, sun damage, melanin

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