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Treatment for primary hypothyroidism: current approaches and future possibilities

Authors Chakera AJ, Pearce SHS, Vaidya B

Published 22 December 2011 Volume 2012:6 Pages 1—11


Review by Single-blind

Peer reviewer comments 2

Ali J Chakera1, Simon HS Pearce2, Bijay Vaidya1
1Department of Endocrinology, Royal Devon and Exeter Hospital and Peninsula Medical School, Exeter, 2Endocrine Unit, Royal Victoria Infirmary and Newcastle University, Newcastle upon Tyne, UK

Abstract: Primary hypothyroidism is the most common endocrine disease. Although the diagnosis and treatment of hypothyroidism is often considered simple, there are large numbers of people with this condition who are suboptimally treated. Even in those people with hypothyroidism who are biochemically euthyroid on levothyroxine replacement there is a significant proportion who report poorer quality of life. This review explores the historical and current treatment options for hypothyroidism, reasons for and potential solutions to suboptimal treatment, and future possibilities in the treatment of hypothyroidism.

Keywords: primary hypothyroidism, levothyroxine, triiodothyronine, thyroid-stimulating hormone, thyroid

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