Back to Archived Journals » Reports in Parasitology » Volume 4

Toxoplasma gondii infection and neuropsychiatric disease: current insight

Authors Hinze-Selch D

Received 24 March 2015

Accepted for publication 14 June 2015

Published 22 September 2015 Volume 2015:4 Pages 43—51

DOI https://doi.org/10.2147/RIP.S52980

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Editor who approved publication: Professor Xun Suo


Dunja Hinze-Selch

Fachkliniken St. Marien – St Vitus GmbH, Fachklinik St Marienstift Dammer Berge, Neuenkirchen-Vörden, Germany

Abstract: Toxoplasma gondii has always been associated with severe medical disease when acquired congenitally or under immunocompromised conditions. However, in the last decade, intensive research has shed light on Toxoplasma gondii as a latent chronic infection producing distinct neuropsychiatric symptoms and alterations in its intermediate hosts, such as humans and rodents. The peculiarities described range from the well-established attenuated odor aversion paradigm toward cat urine, in infected rodents to significant associations with psychiatric disorders such as schizophrenia or bipolar disorder, to cognitive impairments, and increased traffic accidents. In relation to what has already been investigated to date, how could we explain such effects on the basis of what we know about the complex interplay of this intracellular permanent parasite and its host? This review systematically screens the recent literature, presents results from a physician's point of view, and discusses possible mechanisms and further research lines.

Keywords: Toxoplasma gondii, neuropsychiatric, psychiatric, behavior

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]