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Titration of amlodipine to higher doses: a comparison of Asian and Western experience
Authors Kario K, Robbins J, Jeffers BW
Received 17 June 2013
Accepted for publication 12 August 2013
Published 5 November 2013 Volume 2013:9 Pages 695—701
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 4
Kazuomi Kario,1 Jeffery Robbins,2 Barrett W Jeffers2
1Division of Cardiovascular Medicine, Jichi Medical University, Shimotsuke, Japan; 2Pfizer, New York, NY, USA
Abstract: In this retrospective analysis, data pooled from two Phase III/IV open-label Asian studies were used to quantify the additional blood pressure efficacy achieved when titrating amlodipine from 5 mg to 10 mg in mild/moderate hypertensive patients, and compared to data pooled from three Western studies. The primary efficacy end point was the change from baseline in sitting systolic blood pressure (SBP) and diastolic blood pressure (DBP) to the specified time point (4–8 weeks, depending on the trial). For the Asian analysis (n=174), both mean SBP and DBP were significantly decreased at the final visit (SBP -13.3 mmHg, 95% confidence interval [CI] -15.5 to -11.0; DBP -9.2 mmHg, 95% CI -10.6 to -7.8; both P<0.0001). These results were similar to the Western analysis (n=369; SBP -11.5 mmHg, 95% CI -13.1 to -10.0; DBP -6.3, 95% CI -7.1 to -5.5; both P<0.0001). In summary, titration of amlodipine from 5 mg to 10 mg significantly decreased both SBP and DBP in Asian patients with mild-to-moderate hypertension.
Keywords: amlodipine, hypertension, Asia
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