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Thyroid Eye Disease: How A Novel Therapy May Change The Treatment Paradigm

Authors Wang Y, Patel A , Douglas RS

Received 23 July 2019

Accepted for publication 8 September 2019

Published 11 November 2019 Volume 2019:15 Pages 1305—1318


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Professor Garry Walsh

Yao Wang,1 Amy Patel,1 Raymond S Douglas1,2

1Department of Surgery, Division of Ophthalmology, Cedars Sinai Medical Center, Los Angeles, CA, USA; 2State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, People’s Republic of China

Correspondence: Raymond S Douglas
Cedars Sinai Medical Center, West Medical Office Towers, 8635 W Third St, Suite 650W, Los Angeles, CA 90048, USA
Tel +1 310-423-8789
Fax +1 310-248-8596
Email [email protected]

Abstract: Thyroid eye disease (TED) is a complex, debilitating autoimmune disease that causes orbital inflammation and tissue remodeling, resulting in proptosis, diplopia, and in severe cases, loss of vision. TED can lead to facial disfigurement and severely impact patients’ quality of life. Although the course of TED was identified over 60 years ago, effective treatment options have proved to be challenging. Current treatments such as glucocorticoid therapy and orbital radiation focus on reducing orbital inflammation. However, these therapies fail to modify the disease outcomes, including proptosis and diplopia. Recent advances in the understanding of the molecular basis of TED have facilitated the development of targeted molecular therapies such as teprotumumab, an insulin-like growth factor-1 receptor inhibiting monoclonal antibody. In recent phase 2 and phase 3 randomized placebo-controlled trials, teprotumumab rapidly achieved improvement in clinical endpoints defining TED, including improved proptosis and diplopia. Dramatic improvement in clinical outcomes achieved after teprotumumab therapy during active TED are heretofore singular and comparable only to surgical therapies achieved during the inactive phase of TED. The advent of effective medical therapy can lead to a paradigm shift in the clinical management of TED. This review will provide an overview of TED, its epidemiology, insight into the molecular biology of the disease, clinical characteristics and diagnosis, and current and emerging treatment modalities.

Keywords: thyroid eye disease, proptosis, clinical activity score, insulin-like growth factor-1R, teprotumumab


Thyroid eye disease (TED) is a complex autoimmune disease characterized by orbital inflammation (active disease), with subsequent tissue remodeling and fibrosis when the disease becomes inactive.2,3 As TED progresses, it leads to proptosis, strabismus, corneal ulceration, and even optic neuropathy.2,4,5

Several treatment strategies are available, which focus on immune suppression.1 Though some provide short-term relief, they do not necessarily lead to disease course modification.2 The management of TED remains a major clinical and therapeutic challenge, as insufficient treatment can negatively impact patients’ quality of life (QoL).2,6,7 Consequently, there is still an unmet need for an effective disease-modifying treatment with a balanced safety-risk profile.2,8,9 This review provides an overview of TED, its epidemiology, molecular biology, clinical characteristics and diagnosis, and current and emerging treatment modalities, including teprotumumab, an insulin-like growth factor-1 receptor (IGF-1R) inhibitor antibody.

Thyroid Eye Disease Epidemiology

TED is most often associated with Graves’ disease (GD), but also can occur in association with hypothyroidism, euthyroidism, and Hashimoto’s thyroiditis.1,1013 GD affects approximately 1% to 2% of the adult population,8 with an estimated 40% of GD patients subsequently developing TED over the course of their lifetime.14 The onset of TED typically occurs between 30 and 50 years of age, with the disease course more severe after age 50.10,15

TED often occurs within 18 months following a GD diagnosis.16 It can, however, be diagnosed simultaneously or even before the diagnosis of GD.17

In Europe, the reported prevalence of active and inactive TED is 10/10,000 individuals.18 The only US study on incidence of TED was completed in the 1990s and indicates that the age-adjusted incidence rate for females is 16 cases/100,000 population/year, and 2.9 cases/100,000 population/year for males.19 TED is 2.5- to 6-fold more common among women than men, but is on average, more severe in men.15 Active TED is much less prevalent due to its defined disease course and moderate-to-severe TED occurs in less than 5/10,000 individuals.18 About 37% of the overall TED population has active disease at any one time.20

Risk Factors

Untreated thyroid dysfunction (hyper- or hypothyroidism) is associated with the development and progression of TED.21 Smoking is the strongest risk factor associated with TED. The risk of developing TED has a greater association with the amount of cigarettes smoked following the diagnosis of GD rather than the cumulative cigarettes smoked.22 Further, radioactive iodine, a commonly used treatment for hyperthyroidism, is also a known risk factor for both development and progression of TED.23 Concomitant glucocorticoid usage appears to decrease the risk of the development or worsening of TED associated with radioactive iodine therapy.21,24

Molecular Biology Of Thyroid Eye Disease

A complete understanding of the pathophysiology of TED has not been delineated, but evidence suggests that disease pathogenesis is related to loss of self-tolerance to thyroid-stimulating hormone receptor (TSH-R) and overexpression of IGF-1R.8,2527 The autoimmune orbital response occurs in TED because of cross-reactivity against antigens that are present in both the thyroid gland and orbital tissue, although the exact pathophysiology is still unclear.11,28 It appears that the production of thyroid-stimulating immunoglobulins (TSIs) mimics thyroid-stimulating hormone (TSH), leading to excessive thyroid hormone production and amplified actions on target tissues expressing TSH-R (ie, orbital fat, extraocular muscle, and orbital fibroblasts).25 While TSI levels tend to be higher in patients with severe, active TED, a significant correlation between TSI levels and the disease course is lacking.14 Therefore, measuring TSI levels is not considered a predictable biomarker to guide the clinical management of TED.14

Investigations to determine the underlying cause of TED have recently focused on IGF-1R, as IGF-1R autoantibodies have been detected in GD patients.29 IGF-1R, which is overexpressed in TED, forms a physical and functional interactive complex with TSH-R in orbital fibroblasts.27 TSH-R and IGF-1R are involved in orbital tissue reactivity and remodeling via production of proinflammatory cytokines and synthesis of hyaluronan (Figure 1).8,2527,3032 IGF-1R is overexpressed in T cells, B-cells, fibroblasts, myofibroblasts, and fibrocytes in patients with GD.3336 Furthermore, both IGF-1 and Graves’ disease-IgG increase hyaluronan concentrations to a similar extent in orbital fibroblasts from GD patients, but not in those from normal controls. These findings indicate an important role for IGF-1R in the pathogenesis of TED.37

Figure 1 Pathophysiology of thyroid eye disease. In TED, B-lymphocytes, T-lymphocytes, and CD34+ fibrocytes infiltrate the orbit. CD34+ fibroblasts, originating from bone marrow-derived fibrocytes, further differentiate into myofibroblasts or adipocytes. Both CD34+ and residential CD34− fibroblasts are present within the orbit, and depending upon microenvironment-mediated signaling, can produce cytokines, including IL-1β, IL-6, IL-8, IL-16, TNF-α, RANTES, and CD40 ligand, which activate orbital fibroblasts. CD34+ fibroblasts express low levels of TSH-R, thyroglobulin, and additional thyroid antigens. TSIs activate the TSH-R/IGF-1R complex inducing inflammatory molecule expression and glycosaminoglycan synthesis. Furthermore, immunoglobulins directed against IGF-1R induce orbital fibroblast signaling, thereby increasing cytokine and hyaluronan production, and subsequent orbital tissue expansion, leading to proptosis and compression of the optic nerve. Adipogenesis also leads to orbital fat expansion. From N Engl J Med, Smith TJ, Hegedus L, Graves’ disease, 375(16), 1552–1565. Copyright © (2016) Massachusetts Medical Society. Reprinted with permission from Massachusetts Medical Society.4 Abbreviations: IGF-1R, insulin-like growth factor-1 receptor; IL, interleukin; MHC, major histocompatibility complex; RANTES, Regulated on Activation, Normal T Cell Expression and Secreted); TED, thyroid eye disease; TGF-β, transforming growth factor beta; TNF-α, tumor necrosis factor alpha; TSH-R, thyroid-stimulating hormone receptor; TSI, thyroid-stimulating immunoglobulins.

Clinical Characteristics And Diagnostic Criteria Of Thyroid Eye Disease

Clinical manifestations of active TED can vary and may include conjunctival chemosis and injection, lid swelling, lid retraction, proptosis, strabismus, exposure keratopathy, and optic neuropathy (Figure 2).38 Common symptoms may include eye pain, excessive lacrimation, diplopia, photophobia, and blurry vision.39 According to a cohort of patients with TED in Minnesota, eyelid retraction was the most common clinical finding (90.8% of patients).39 Upper eyelid retraction was present in >70% of patients, followed by proptosis (62%), restrictive myopathy (43%), and optic neuropathy (6%).39 Upper eyelid retraction, along with proptosis resulting in lagophthalmos, can cause exposure keratopathy and ulceration. Dysfunction of Bell’s phenomenon due to inferior rectus restriction can further worsen corneal exposure.1,40 Soft tissue expansion and swelling of the brow fat and the premalar region can also occur in patients with TED, though with a much lower occurrence rate (2%).41,42

Figure 2 Clinical characteristics of thyroid eye disease. (A) Moderate active TED: lid retraction with evidence of orbital tissue inflammation; (B) Moderate inactive TED: lid retraction; (C) Severe active TED: upper eyelid retraction and binocular soft tissue inflammation; (D) Severe inactive TED: lid retraction with proptosis. Reproduced from Li Q, Ye H, Ding Y, et al. Clinical characteristics of moderate-to-severe thyroid associated ophthalmopathy in 354 Chinese cases. PLoS One. 2017;12(5):e0176064. Creative Commons License and Disclaimer available from: TED, thyroid eye disease.

The most feared complication of TED is dysthyroid optic neuropathy. Risk factors include older age, male gender, and smoking.43,44 The onset of dysthyroid optic neuropathy can be gradual and subtle, with decreased color vision as the most common presenting feature. Visual field defects may also be present.45 A European Group on Graves’ Orbitopathy (EUGOGO) study investigated characteristics of patients with dysthyroid optic neuropathy.46 A significant portion of these patients lacked severe inflammation and congestion, as 28% of patients with TED had a clinical activity score (CAS) of three or less.1,46 Therefore, clinical activity score should not be considered as a correlate to optic neuropathy in clinical management, as it can potentially delay treatment. Further, color vision was abnormal in the majority of patients. Exophthalmometry was greater than 20 mm in two-thirds of the patients. Visual field defects included arcuate or altitudinal defects, central/paracentral scotomas, or generalized depression.40 Most of these patients had normal appearing optic nerves.46 Apical muscle crowding was seen in 88% of patients with dysthyroid optic neuropathy.46 If there is a delay in treatment, patients can develop permanent optic nerve atrophy and irreversible vision loss.

The clinical course of TED frequently follows a pattern first described over 60 years ago by Francis Rundle (Figure 3).47 Active TED is an inflammatory, progressive disease characterized by orbital or periorbital inflammation. It generally lasts from 6 to 24 months, but can be present for up to 3 years. The disease then progresses to stable, chronic, fibrotic, inactive disease. Despite reduced inflammation, permanent damage may result and patients do not typically experience significant clinical improvement, responding only to surgery at this point.11

Figure 3 An approximation of a curve depicting severity of thyroid eye disease over time that is based on a concept by Rundle.110

Once the patient’s disease progresses to inactive TED, their clinical course is typically stable. A small percentage (5–16%) of patients can experience reactivation of the inflammatory phase, with worsening proptosis as the most common clinical presentation.48,49 Risk factors include smoking during initial TED presentation, periocular surgery, pregnancy, and uncontrolled hypo- or hyperthyroidism.4851

Various outcome assessment scales are used in clinical trials, and to a lesser extent in practice, to evaluate effectiveness of therapies for TED.1 CAS assesses the presence of inflammatory symptoms and was initially developed to identify active inflammation to help predict glucocorticoid therapy response (Table 1).16 It is used to help identify active TED patients and document their response to treatment over time.52 A list of seven inflammatory orbital symptoms representing pain, redness, and swelling constitute the CAS with the presence of three or more indicating the patient is active.52 The list can be expanded to 10 symptoms for follow-up.52 There are several classification systems in rather limited use (eg, NOSPECS [No physical signs or symptoms, Only signs, Soft tissue involvement, Proptosis, Extraocular muscle signs, Corneal involvement, and Sight loss; Table 2], VISA [Vision, Inflammation, Strabismus, and Appearance], and EUGOGO).11,52

Table 1 Clinical Activity Scorea

Table 2 NOSPECS Classification

In clinical practice, TED is generally diagnosed via a combination of medical history, presenting symptoms, radiographic imaging, and laboratory results (eg, TSH, TSI, thyroid peroxidase antibody, and TSH-R antibody levels).1,11 However, not every clinician chooses the same combination of diagnostic tools, and there continues to be a lack of standardization. Improved assessment techniques in the future may be beneficial to better guide clinicians.16

Treatment Modalities For Thyroid Eye Disease

Treatment options for TED generally depend on disease activity and severity (Table 3).1,53 Active and inactive TED can vary in severity, typically described as mild, moderate-to-severe, or sight-threatening.1 In active, mild TED, ocular lubricants, sunglasses, and prisms are used for supportive management.10,53 For active, moderate or severe disease, a variety of treatment strategies are used, sometimes resulting in short-term relief. However, there is still an unmet need for disease-modifying treatments with an optimal safety profile and long-term benefits.1,2

Table 3 Current And Emerging Therapies For Thyroid Eye Disease

Orbital Radiation

Orbital radiation (OR) has been used for the treatment of TED for several decades, and is generally well-tolerated.54 The rationale for its use is two-fold. The first lies in its nonspecific anti-inflammatory effect, and the second is the radio-sensitivity of orbit-infiltrating lymphocytes.54,55 Additionally, OR may target fibroblasts leading to reduced glycosaminoglycan synthesis and secretion.56

However, due to non-standardized protocols and relative lack of randomized clinical trial results, the use of OR is not without controversy. Three randomized clinical trials found differing results. While Gorman et al did not find a difference between OR and sham therapy,57 Mourits et al found OR to be superior to sham.58 Prummel et al found OR to be effective in reducing diplopia and improving extraocular muscle motility in patients with mild TED, although there was no effect on QoL or disease progression.59 Further studies evaluating concomitant OR with intravenous (IV) or oral glucocorticoids also yielded dissimilar results.6063 A report from the American Academy of Ophthalmology concluded that there is considerable heterogeneity and variability in the quality of studies assessing the benefit of OR for the treatment of TED.64 Overall, OR appears to offer little, if any, long-term clinical benefit.



In Europe, glucocorticoids are considered the first-line treatment for active TED to reduce edema and orbital inflammation, as recommended by the EUGOGO guidelines.1 IV pulse glucocorticoid administration is preferred to oral administration, as it has a more favorable efficacy and safety profile.8,10 However, high-dose systemic glucocorticoid therapy can have undesired adverse effects, including the development of Cushingoid features, hypertension, hyperglycemia, mood instability, weight gain, and osteoporosis.10 Although glucocorticoids are frequently used in the treatment of TED, their therapeutic efficacy has not been confirmed by adequate placebo-controlled trials to date.14 In a study investigating three cumulative IV doses of methylprednisolone (2.25 g, 4.98 g, and 7.47 g) in patients with active, moderate-to-severe TED, the 7.47 g dose (over a 12-week period) reduced CAS and mildly improved ocular motility.65 However, it did not improve proptosis or diplopia significantly and was associated with significant adverse events (AEs), such as diabetes mellitus, psychosis, and depression.65 Furthermore, the only placebo-controlled trial showed that methylprednisolone pulse therapy did not significantly improve mean proptosis or diplopia.66 Diplopia improved in 50% (2/4) of methylprednisolone-treated patients compared with 0% (0/5) of placebo-treated patients, although the improvement was not statistically significant (P = 0.073). Proptosis improved in 40% (2/5) of methylprednisolone-treated patients and in 29% (2/7) of placebo-treated patients, which was also not statistically significant (P = 0.68).66

Periocular and orbital glucocorticoid administration are alternative proposed treatment options that can limit systemic side effects. A multicentered, randomized, controlled study found that patients who received four inferolateral orbital injections of 20 mg of triamcinolone acetate 40 mg/mL (24 patients vs 17 patients in the control group) experienced improvement in diplopia, with radiographic imaging showing a reduction in the size of extraocular muscles.67 Although patients also reported fewer side effects, these treatments failed to demonstrate consistent efficacy. Larger trials are needed to fully evaluate the efficacy of locally administered glucocorticoids.67


Mycophenolate mofetil (MMF), an immunosuppressant, is converted to mycophenolic acid (MPA) via the action of hepatic esterase and inhibits guanosine monophosphate synthesis (de novo purine synthesis).68,69 MPA potently inhibits the type 2 isoform of inosine monophosphate dehydrogenase, thereby inhibiting lymphocyte proliferation.68,70 This immune modulatory effect led to the evaluation of MPA for the treatment of TED.6870

The safety of MPA in patients with active, moderate-to-severe TED was evaluated in a prospective longitudinal study over 24 weeks, with concomitant intravenous steroids during the first 12 weeks.68 AEs were reported in 68% (36/53) of patients.68 Serious AEs were reported in 13% (7/53) of patients, but none were considered treatment-related.68

Mycophenolate was subsequently evaluated in combination with methylprednisolone in active, moderate-to-severe TED in a randomized, observer-masked, multicenter, open-label 36-week trial.70 The primary outcome was not met, although statistically significant improvements were noted in the methylprednisolone plus mycophenolate groups at both 24 and 36 weeks in post hoc analyses.70 Overall, cumulative results suggest that MMF may be a well-tolerated option to treat TED, but it appears to offer minimal long-term benefit.69


Cyclosporine, alone or in combination with glucocorticoid therapy, has been proposed as an effective treatment for TED.71,72 A randomized controlled trial compared cyclosporine plus prednisone to prednisone only for 10 weeks.72 A greater improvement in CAS and visual acuity were observed with combination therapy at 10 weeks when compared with prednisone monotherapy at 10 weeks (P <0.001 and P <0.01, respectively).72 However, after 10 weeks, there were no significant improvements in proptosis, CAS, or visual acuity. Moreover, relapses occurred in 40% (8/20) of patients in the prednisone group during the following 6 months and in 5% (1/20) in the combined treatment group at 9 months.72 AEs included increased liver enzymes and hypertension.72 In another study, the response in total eye score after 12 weeks with prednisone alone was 61% (11/18) as compared with 22% (4/18) for the cyclosporine only group (P = 0.018).71 However, neither group had significant improvement in proptosis or eye muscle score.71 Patients in both groups who did not respond received combination therapy of cyclosporine and a low dose of prednisone for an additional 12 weeks and overall response was improved in some patients. Again, there was no consistent benefit in mean proptosis or eye muscle score from 12 to 24 weeks.71 Therefore, cyclosporine may offer improved anti-inflammatory potential, but there is no data to suggest long-term clinical improvement in proptosis or strabismus.


Studies have shown that high dose IV immunoglobulin is as effective as high doses of oral glucocorticoids.73,74 However, this is not routinely used today for the treatment of TED. Other immunosuppressive medications, such as somatostatin analogues, azathioprine, and ciamexone have, in aggregate, been found ineffective in the treatment of TED.7580

Surgical Management Of Thyroid Eye Disease

Surgical intervention for TED is typically a multi-staged approach of sequential orbital decompression, eye muscle surgery, and/or eyelid surgery.1 Most patients with TED will not require surgical intervention, with previous reports showing that 20% of patients undergo ≥1 surgical procedures.81 The probability of undergoing surgery was 5% at 1 year after diagnosis, 9.3% at 2 years, 15.9% at 5 years, and rose to 21.8% at 10 years.81 Up to 27% of patients are offered surgery after the disease becomes inactive.20 The need for surgical intervention increased with age, with patients aged ≥50 years having a 2.6-times greater risk.81

Surgical decompression is generally performed on TED patients with inactive stable disease, but also can be used for active patients when vision is threatened by compression optic neuropathy.11,16 The orbital surgeon may decide to perform fat decompression as well as bony decompression.1 In general, between 5% and 20% of TED patients will undergo decompression surgery.82 Unfortunately, orbital surgery can reactivate inflammation, exacerbating ophthalmopathy, and orbital decompression can cause strabismus in one-third of patients.2,83

The enlargement and fibrosis of extraocular muscles in TED can cause restrictive strabismus and diplopia, which can significantly affect QoL.84 The inferior and medial recti muscles are most commonly affected. Strabismus surgery is typically performed following orbital decompression, due to the risk of worsening of diplopia.1 The primary goal of strabismus surgery is for binocular vision in primary gaze and down gaze, and secondarily to improve the window of single binocular vision.85 The typical surgical plan includes recession of the restricted muscle. It is important to discuss expectations, as patients may need additional strabismus surgery or require the aid of prisms.

Upper eyelid retraction is the most common feature of TED.86 Its pathophysiology includes GD-induced sympathetic excess and eyelid fibrosis. Upper eyelid retraction, along with proptosis, can cause exposure keratopathy and ulceration due to lagophthalmos. There are various techniques to correct upper eyelid retraction, including graded müllerectomy or full thickness blepharotomy.87,88 Good, predictable results have been achieved with these different procedures, and treatment decision is ultimately guided by surgeon preference and experience.

Similarly, lower eyelid retraction is theorized to be caused by sympathetic overstimulation and fibrosis.89 A transconjunctival approach is typically favored, in which the lower eyelid retractors are recessed or separated. Spacer grafts (homologous, autologous, or alloplastic material) can be used if the retraction is severe.90,91

Smoking Cessation

As previously mentioned, cigarette smoking is a significant risk factor for the development and progression of TED.92 Microarray analysis of intra-orbital fat from both smokers and nonsmokers with active TED revealed differences in gene expression, including 103 genes that were upregulated and 54 genes that were downregulated.93 In particular, IL-1β and IL-6 expression were upregulated 2.3-fold (P = 0.03) and 2.4-fold (P = 0.004), respectively, in intraorbital fat from smokers with TED compared with their nonsmoker counterparts.93

A prospective study demonstrated the negative impact of smoking on the treatment response following OR or glucocorticoid therapy in patients with active, moderate TED. A greater number of nonsmokers had improved motility (60% vs 24%, P <0.017) and reduction in CAS compared with smokers after 12 months (P <0.05).22 However, no significant changes were observed in proptosis after 12 months.22 Patients should be advised that smoking exacerbates the severity of ophthalmopathy and lessens the response to treatment.94


Selenium was evaluated as a therapeutic option in a randomized, double-blind, placebo-controlled trial in euthyroid patients with mild TED.95 Patients were treated with 100 µg sodium selenite twice per day for 6 months with an additional 6-month follow-up period.95 The selenium-treated patients had a significant improvement in QoL and CAS, compared with placebo at 6 and 12 months (P <0.001). Symptomatic improvement was observed in 61% (33/54) of the selenium-treated patients compared with 36% (18/50) of the placebo group.95 Furthermore, only 7% (4/54) of patients in the selenium group had disease progression, compared with 26% (13/50) in the placebo group.95 Selenium was not associated with any AEs.95 However, no significant changes in proptosis at 6 or 12 months were reported.95 Limitations of this study included the lack of serum selenium assessment at baseline and throughout the study.95 Since most patients originated from areas where the general population has marginally reduced selenium levels, a slight selenium deficiency may have confounded a beneficial effect upon supplementation.95 The reported beneficial effects of selenium have not been demonstrated in a selenium-rich or nondeficient population to date.


Other antioxidants, such as allopurinol and nicotinamide, have been suggested to improve visual acuity, reduce differential pressure, and improve ocular motility in patients with TED. However, there is insufficient clinical data to demonstrate benefits or efficacy.96,97 These antioxidants are not routinely used in clinics and are not approved for treatment of TED.

Novel, Targeted Biological Therapies

Thyroid-Stimulating Hormone Receptor Inhibitors

Antibodies that inhibit the TSH-R are under consideration as potential treatment options for TED.25 An array of small-molecule TSH-R antagonists have been tested in vitro and in vivo in preclinical models, but no robust clinical trials have been conducted to date.25


Tocilizumab, an IL-6 receptor monoclonal antibody, is approved for the treatment of active, moderate-to-severe rheumatoid arthritis and giant cell arteritis and is under consideration as a potential treatment for TED.9,98,99 IL-6 is a proinflammatory cytokine produced by a variety of cells, including fibroblasts, monocytes, and T and B lymphocytes, which are implicated in the disease process of TED.9 It is found in high concentrations in the serum of patients with TED100 A small study showed that tocilizumab reduced inflammation in patients who were unable to tolerate glucocorticoids.101 A more recent randomized clinical trial (NCT01297699) showed that 93.3% of patients treated with tocilizumab vs 58.8% receiving placebo met the primary endpoint of reduction of CAS by ≥2 points at week 16 (P = 0.04; odds ratio, 9.8; 95% confidence interval [CI] 1.3–73.2).102 However, tocilizumab did not significantly improve diplopia. In addition, although tocilizumab significantly improved median proptosis at week 16 compared with placebo (P = 0.003), the magnitude of the reduction from baseline was only 1.5 mm, which may not be a clinically significant reduction.102 At week 40, 93 AEs were reported among 27 patients; the most common being headache (11 tocilizumab vs 4 placebo) and infections (17 vs 7). There were serious AEs in 2 patients receiving tocilizumab (one with a moderate increase in transaminase levels, attributed to latent tuberculosis, and another with acute pyelonephritis).102

Anti-tumor Necrosis Factor-Alpha Agents

In a small retrospective, off-label study, there was subjective improvement in diplopia, pain, and swelling in 40% (4/10) of patients; following 3 months of adalimumab therapy (an initial injection of 80 mg followed by 40mg injections twice per week). However, there were no significant improvements in proptosis or extraocular movement restriction.103 A case report showed that an infliximab infusion improved symptoms (pain related to corneal exposure and ocular movement), visual acuity, color vision, and CAS.104 While these findings suggest that anti-tumor necrosis factor-alpha agents may benefit some TED patients, larger studies are needed to confirm their efficacy and safety.105


Rituximab is a chimeric monoclonal antibody targeting CD20, a membrane-embedded protein expressed on the surface of pre-B and mature B lymphocytes.106 Since rituximab depletes CD20-carrying B-cells, it was proposed as a potential treatment for TED.8 Two small controlled trials were conducted to evaluate the efficacy of rituximab,80,107 with inconsistent results. In one study, rituximab (500 mg or 2000 mg) and IV methylprednisolone (7.5 g) both decreased CAS (more pronounced in the rituximab group compared to IV methylprednisolone at 16, 20, and 24 weeks).107 After 24 weeks, 15/15 (100%) patients on rituximab improved (decrease of ≥2 points in CAS and CAS <3), compared with 11/16 (69%) patients with CAS <3 (P <0.05) and 12/16 (75%) with a CAS decrease by ≥2 points (NS) in the IV methylprednisolone group.107 However, none of the patients receiving rituximab had ≥2 mm reductions in proptosis at week 24.107 In the second study, 25 patients were administered 2 infusions of rituximab (1000 mg each) or IV normal saline 2 weeks apart.80 At 24 and 52 weeks, rituximab did not significantly improve CAS, proptosis, diplopia, or QoL, and did not reduce orbital fat/muscle volume.80 In summary, rituximab was associated with AEs and has shown no benefits over placebo with respect to the major serious outcomes of TED, such as proptosis and diplopia.80


Teprotumumab, an IGF-1R inhibitory antibody, binds with high affinity and specificity to IGF-1R,35 inducing internalization and degradation of the antibody-receptor complex.14 In vitro studies show that IGF-1R and TSH-R form a physical complex.2,27,35 Production of proinflammatory cytokine (eg, IL-6 and IL-8) is increased via IGF-1R/TSH-R–mediated activation of fibroblasts.35 In vitro studies showed that teprotumumab attenuates such TSH-mediated cytokine production by reducing IGF-1R and TSH-R cell surface expression.35 Moreover, teprotumumab inhibits IGF-1 and TSH-mediated Akt phosphorylation, thereby attenuating IGF-1R and TSH-R–mediated signaling.35 Therefore, teprotumumab reduces hyaluronan production and cytokine stimulation in orbital fibroblasts,32,35 leading to reduced intraorbital hyaluronan accumulation and reduced adipogenesis and muscle expansion (Figure 4).2

Figure 4 Mechanism of action of teprotumumab. (A) Evidence suggests that TED occurs due to upregulation of the TSH-R/IGF-1R complex consequential to pathogenic autoantibody (GD-IgG and TSI) stimulation of fibroblasts. Such activation leads to the production of glycosaminoglycans (eg, hyaluronan), and expansion of fat and muscle next to the eye.2 (B) Teprotumumab attenuates pathogenic autoantibody-mediated stimulation of orbital fibroblasts, thereby inhibiting TSH-R signaling, and correcting active TED endpoints, including proptosis and diplopia.35,108 Modified from Douglas RS. Teprotumumab, an insulin-like growth factor-1 receptor antagonist antibody, in the treatment of active thyroid eye disease: a focus on proptosis. Eye (Lond). 2019;33(2):183–198. Creative Commons License and Disclaimer available from: Abbreviations: GD-IgG, Graves’ disease immunoglobulins; IGF-1R, insulin-like growth factor-1 receptor; TED, thyroid eye disease; TSH-R, thyroid-stimulating hormone receptor; TSI, thyroid-stimulating immunoglobulin.

The phase 2 multicenter, double-masked, placebo-controlled, randomized clinical trial (NCT01868997) evaluating the efficacy and safety of teprotumumab enrolled 88 patients with recent onset, active, moderate-to-severe TED.108 Patients were randomized (1:1) to receive teprotumumab or placebo.108 Patients received a total of 8 infusions over the 24-week observation period, with 1 IV infusion every 3 weeks, (first dose: 10 mg per kg; subsequent doses: 20 mg per kg; last dose at week 21).108 The primary endpoint was a decrease in CAS of ≥2 points and a reduction in proptosis of ≥2 mm, without an equal deterioration in the nonstudy eye.108 The teprotumumab-treated patients improved significantly compared with the placebo group at 6, 12, 18, and 24 weeks (all P <0.001), with 69% of teprotumumab-treated patients achieving the outcome at 24 weeks (vs 20% of placebo).108 Furthermore, the effect observed after 6 weeks was following only 2 infusions.108 Additionally, 71.4% of teprotumumab-treated patients (vs 20.0% of placebo-treated patients) had ≥2 mm reduction in proptosis at week 24 (P <0.001).2 The greatest improvement was seen in the more severely affected patients,2 with 40% (17/42) of patients receiving teprotumumab experiencing a ≥4 mm reduction in proptosis at week 24 vs 0 (0/45) patients in the placebo group.108 To reduce the chances of variability in evaluation of proptosis, the same type of exophthalmometer was used at each study site and the same site observer completed each patient evaluation. Strikingly, this degree of amelioration in proptosis is consistent with that observed following surgical intervention.2,83,108

QoL was significantly improved vs placebo at each visit following teprotumumab treatment, as determined by the overall Graves’ ophthalmopathy (GO)-QoL scores.108 In addition, a higher number of teprotumumab-treated patients had an improvement in subjectively evaluated diplopia, compared to placebo-treated patients.108 Teprotumumab continued to exert beneficial effects 7 weeks after the final infusion, with the number of patients with reduced CAS and proptosis continuing to increase.108 Furthermore, teprotumumab was well-tolerated and the majority of AEs were mild, well-controlled, and resolved without treatment.108 Hearing impairment was observed in 3 (7%) teprotumumab-treated and 0 placebo-treated patients.108 Hyperglycemia occurred in a small number of patients in both groups. In the teprotumumab-treated group, hyperglycemia was grade 1 in patients with no history of diabetes.108 In diabetic patients, hyperglycemia was grade 2 or 3, and resolved with adjustment of diabetes medication.108 In the teprotumumab-treated patients, hyperglycemia was thought to be due to IGF-1R inhibition, although teprotumumab lacks affinity for the insulin receptor.108 Consequently, recommendations include close monitoring of diabetic patients treated with teprotumumab.108

The findings from the phase 2 trial were recently confirmed with the initial release of results from the phase 3 placebo-controlled trial, which indicated a significant reduction in the primary outcome, defined as the percentage of patients with a ≥2-mm reduction in proptosis at week 24 with teprotumumab vs placebo.109


TED was described over 60 years ago,47 but there have been few advancements in the effective therapeutic management of the disease since.2 Recent developments in the understanding of the molecular basis of TED have led to the development of targeted therapies, such as teprotumumab, which appears to regress the historically resistant progressive outcomes of muscle and fat expansion.2,108 The phase 2 findings, confirmed with the initial release of the phase 3 data, demonstrated dramatic improvement in proptosis and diplopia over the 24-week study periods, and were similar to those obtained with surgery, indicating that there may be yet a viable therapeutic option for patients with active TED.2,108,109


AE, adverse event; CAS, clinical activity score; GD, Graves’ disease; IGF-1R, insulin-like growth factor-1 receptor; IL, interleukin; MMF, mycophenolate mofetil; MPA, mycophenolic acid; OR, orbital radiation; QoL, quality of life; TED, thyroid eye disease; TNF-α, tumor necrosis factor alpha; TSH-R, thyroid-stimulating hormone receptor; TSI, thyroid stimulating immunoglobulins.


The authors would like to thank Robert J. Holt, PharmD, MBA; and Megan Francis-Sedlak, PhD, Medical Affairs, Horizon Therapeutics plc, for helpful discussions. Medical writing and editorial support were provided by Marie-Louise Ricketts, PhD; and Claire Daniele, PhD, of AlphaBioCom, LLC, King of Prussia, PA. Support for preparation of this manuscript was provided by Horizon, Lake Forest, IL. The funder was not involved in writing the article or the decision to submit the article for publication.


Raymond S. Douglas is a consultant for Horizon Therapeutics, plc. The authors report no other conflicts of interest in this work.


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