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Thrombotic microangiopathy associated with use of interferon-beta

Authors Olea T, Diaz-Mancebo, Picazo, Martinez Ara, Robles, Selgas R

Received 25 January 2012

Accepted for publication 6 March 2012

Published 15 June 2012 Volume 2012:5 Pages 97—100


Review by Single anonymous peer review

Peer reviewer comments 5

Teresa Olea,1 Raquel Díaz-Mancebo,1 Maria-Luz Picazo,2 Jorge Martínez-Ara,1 Angel Robles,3 Rafael Selgas,1
1Departments of Nephrology, 2Pathology, 3Internal Medicine, Hospital Universitario La Paz, Madrid, Spain

Abstract: Interferon-beta is widely used for the treatment of relapsing multiple sclerosis. The drug is usually well tolerated, but autoimmune adverse effects, including kidney disease, have been reported. Only a few cases of hemolytic uremic syndrome-thrombotic microangiopathy associated interferon-alpha have been described so far, and even fewer with beta-interferon. We report a patient who developed thrombotic microangiopathy during treatment with interferon-beta and improved after discontinuation and steroid therapy. Complement cascade and antiphospholipid antibodies are investigated. The spectrum of renal diseases associated with interferon-beta treatment is also reviewed.

Keywords: thrombotic microangiopathy hemolytic uremic syndrome, multiple sclerosis, interferon-beta

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