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The Role of Selected Pro-Inflammatory Cytokines in Pathogenesis of Ischemic Stroke

Authors Pawluk H, Woźniak A, Grześk G, Kołodziejska R, Kozakiewicz M, Kopkowska E, Grzechowiak E, Kozera G

Received 8 October 2019

Accepted for publication 13 February 2020

Published 23 March 2020 Volume 2020:15 Pages 469—484

DOI https://doi.org/10.2147/CIA.S233909

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Richard Walker


Hanna Pawluk,1 Alina Woźniak,1 Grzegorz Grześk,2 Renata Kołodziejska,1 Mariusz Kozakiewicz,3 Ewa Kopkowska,1 Elżbieta Grzechowiak,4 Grzegorz Kozera4,5

1Department of Medical Biology and Biochemistry, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland; 2 2nd Department of Cardiology, Faculty of Health Sciences, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland; 3Department of Geriatrics, Division of Biochemistry and Biogerontology, Faculty of Health Sciences, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland; 4Department of Neurology, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland; 5Medical Stimulation Center, Medical University of Gdańsk, Gdańsk, Poland

Correspondence: Hanna Pawluk
Department of Medical Biology and Biochemistry, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Karłowicza 24, Bydgoszcz 85– 092, Poland
Tel +48 52 585 37 55
Email hannapawluk1@wp.pl

Abstract: Stroke is currently one of the most common causes of death and disability in the world, and its pathophysiology is a complex process, involving the oxidative stress and inflammatory reaction. Unfortunately, no biochemical factors useful in the diagnostics and treatment of stroke have been clearly established to date. Therefore, researchers are increasingly interested in the inflammatory response triggered by cerebral ischemia and its role in the development of cerebral infarction. This article gives an overview of the available literature data concerning the role of pro-inflammatory cytokines in acute stroke. Detailed analysis of their role in cerebral circulation disturbances can also suggest certain immune response regulatory mechanisms aimed to reduce damage to the nervous tissue in the course of stroke.

Keywords: cytokines, ischemic stroke, old age disease

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