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The role of chronobiology and circadian rhythms in type 2 diabetes mellitus: implications for management of diabetes

Authors Kurose T, Hyo T, Yabe D, Seino Y

Received 14 February 2014

Accepted for publication 14 May 2014

Published 29 July 2014 Volume 2014:4 Pages 41—49

DOI https://doi.org/10.2147/CPT.S44804

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Takeshi Kurose, Takanori Hyo, Daisuke Yabe, Yutaka Seino

Center for Diabetes, Endocrinology and Metabolism, Kansai Electric Power Hospital, Fukushima, Osaka, Japan

Abstract: Circadian clocks regulate cellular to organic and individual behavior levels of all organisms. Almost all cells in animals have self-sustained clocks entrained by environmental signals. Recent progress in genetic research has included identification of clock genes whose disruption causes metabolic abnormalities such as diabetes, obesity, and hyperlipidemia. Here we review recent advances in research on circadian disruption, shift work, altered eating behaviors, and disrupted sleep-wake cycles, with reference to management of type 2 diabetes.

Keywords: diabetes, clock gene, shift work, eating behavior, sleep loss

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