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The role of brimonidine tartrate gel in the treatment of rosacea

Authors Jackson JM, Knuckles M, Minni J, Johnson S, Belasco K

Received 13 February 2015

Accepted for publication 24 April 2015

Published 23 October 2015 Volume 2015:8 Pages 529—538


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Jeffrey Weinberg

J Mark Jackson,1 Melissa Knuckles,2 John Paul Minni,3 Sandra Marchese Johnson,4, Kevin Tate Belasco5

1Division of Dermatology, University of Louisville, Louisville, KY, USA; 2PSC, Dermatology, Corbin, KY, USA; 3Waters Edge Dermatology, Stuart, FL, USA; 4Johnson Dermatology, Fort Smith, AR, USA; 5Blue Harbor Dermatology, Newport Beach, CA, USA

Abstract: Rosacea is a chronic cutaneous condition with a prevalence rate ranging from 9.6% to 22% in recent studies. Facial erythema (transient and permanent) is considered a common denominator that is frequently observed in all subtypes of rosacea and is estimated to affect more than 40 million people worldwide. Brimonidine tartrate is a selective α2-adrenergic receptor agonist and is the first topical treatment approved for facial erythema of rosacea. Clinical trials have demonstrated that brimonidine tartrate provided significantly greater efficacy, compared to vehicle, for the treatment of moderate to severe erythema of rosacea. In addition, brimonidine tartrate has demonstrated a rapid onset of effect, duration of action throughout the day, and good safety profile in studies of up to 1 year. This review critically discusses the role of brimonidine tartrate for the treatment of facial erythema of rosacea by examining both clinical study data and real-world dermatologist experiences across a wide spectrum of treated patients, and concludes that it is a significant therapeutic option in the management of an unmet need of this chronic condition.

Keywords: rosacea, brimonidine tartrate, erythema, adverse event

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