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The "Pulse Time Index of Norm" highly correlates with the left ventricular mass index in patients with arterial hypertension

Authors Posokhov I, Kulikova N, Starchenkova I, Grigoricheva E, Evdokimov V, Orlov A, Rogoza A

Received 27 November 2013

Accepted for publication 24 January 2014

Published 19 March 2014 Volume 2014:10 Pages 139—144


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Igor N Posokhov,1 Natalya N Kulikova,2 Irina V Starchenkova,2 Elena A Grigoricheva,3 Vitaly V Evdokimov,3 Artemy V Orlov,4 Anatoly N Rogoza5

On behalf of The BPLab-Vasotens Registry Collaborators

1Hemodynamic Laboratory Ltd, Nizhny Novgorod, Russia; 23rd Republican Hospital, Saransk, Russia; 3Chelyabinsk State Medical Academy, Chelyabinsk, Russia; 4National Research Nuclear University MEPhl, Moscow, Russia; 5Cardiology Research Center, Moscow, Russia

Background: Arterial stiffness, as measured by the pulse wave velocity (PWV), is recommended for routine use in clinical practice as an important parameter for the evaluation of cardiovascular risk.1 New 24-hour monitors (eg, with Vasotens® technology; Petr Telegin Company, Nizhny Novgorod, Russian Federation) provide single PWV measurements as well as several PWV measurements over a period of 24 hours.2 Such 24-hour pulse wave analysis led to the development of the novel Pulse Time Index of Norm (PTIN), which is defined as the percentage of a 24-hour period during which the PWV does not exceed the 10 m/second PWV threshold. The aim of this study is to test the new PTIN for correlation with the left ventricular mass index (LVMI).
Methods: Oscillometrically generated waveform files (n=137) used for clinical research studies were reanalyzed using the new 2013 version of the Vasotens technology program, which enables PTIN calculations.
Results: A good correlation (r=−0.72) between the PTIN and the LVMI was shown, which was significantly above the blood pressure load (r=0.41).
Conclusion: The PTIN generated by the Vasotens technology can be recommended as an indicator of end organ damage via hypertension.

Keywords: pulse wave velocity, ambulatory, 24-hour, monitoring, PTIN, arterial stiffness, LVMI

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