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The pharmacology of neurokinin receptors in addiction: prospects for therapy

Authors Sandweiss A, Vanderah T

Received 25 June 2015

Accepted for publication 23 July 2015

Published 7 September 2015 Volume 2015:6 Pages 93—102

DOI https://doi.org/10.2147/SAR.S70350

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr LaTrice Montgomery

Peer reviewer comments 2

Editor who approved publication: Professor Li-Tzy Wu


Video abstract presented by Alexander J Sandweiss and Todd W Vanderah.

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Alexander J Sandweiss, Todd W Vanderah

Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, USA

Abstract:
Addiction is a chronic disorder in which consumption of a substance or a habitual behavior becomes compulsive and often recurrent, despite adverse consequences. Substance p (SP) is an undecapeptide and was the first neuropeptide of the neurokinin family to be discovered. The subsequent decades of research after its discovery implicated SP and its neurokinin relatives as neurotransmitters involved in the modulation of the reward pathway. Here, we review the neurokinin literature, giving a brief historical perspective of neurokinin pharmacology, localization in various brain regions involved in addictive behaviors, and the functional aspects of neurokinin pharmacology in relation to reward in preclinical models of addiction that have shaped the rational drug design of neurokinin antagonists that could translate into human research. Finally, we will cover the clinical investigations using neurokinin antagonists and discuss their potential as a therapy for drug abuse.

Keywords: reward, substance p, alcohol, morphine, cocaine, dopamine

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