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The occurrence of cerebrovascular atherosclerosis in Alzheimer’s disease patients

Authors Yuan J, Wen G, Li Y, Liu C

Received 18 February 2013

Accepted for publication 13 March 2013

Published 24 May 2013 Volume 2013:8 Pages 581—584

DOI https://doi.org/10.2147/CIA.S44160

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Jing Yuan,1,* Ge Wen,2,* Yingjia Li,3 Changxing Liu1

1Department of Medical Information, General Hospital of Jinan Military Command, Jinan, People’s Republic of China; 2Imaging Center, Nanfang Hospital of Southern Medical University, Guangzhou, People’s Republic of China; 3Ultrasound Diagnosis Department, Nanfang Hospital of Southern Medical University, Guangzhou, People’s Republic of China

*These authors contributed equally to this work

Background: Both Alzheimer’s disease (AD) and cerebrovascular atherosclerosis (CA) contributed to dementia in an aged population. Whether they share the same mechanism is unknown.
Aim: Our goal was to explore the occurrence rates of CA in AD patients.
Method: Here we examined the degree of CA in different groups of AD patients with contrast angiography. Ninety-three AD patients were recruited to the present study. Contrast computed tomography scanning and contrast angiography were performed for CA analyses.
Result: We found that the cerebrovascular plaques were common in AD patients, which was partly correlated with the severity of AD (as determined by cognitive decline).
Conclusion: We concluded that vascular dementia may partly correlate with AD pathology.

Keywords: Alzheimer’s disease, cerebrovascular atherosclerosis, aging, patients

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