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The effects of graphene and mesenchymal stem cells in cutaneous wound healing and their putative action mechanism

Authors Lasocka I, Jastrzębska E, Szulc-Dąbrowska L, Skibniewski M, Pasternak I, Hubalek Kalbacova M, Skibniewska EM

Received 15 October 2018

Accepted for publication 9 January 2019

Published 1 April 2019 Volume 2019:14 Pages 2281—2299

DOI https://doi.org/10.2147/IJN.S190928

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Govarthanan Muthusamy

Peer reviewer comments 3

Editor who approved publication: Dr Thomas Webster


Iwona Lasocka,1 Elżbieta Jastrzębska,2 Lidia Szulc-Dąbrowska,3 Michał Skibniewski,4 Iwona Pasternak,5 Marie Hubalek Kalbacova,6,7 Ewa M Skibniewska1

1Department of Animal Environment Biology, Faculty of Animal Science, Warsaw University of Life Sciences, Warsaw, Poland; 2Department of Medical Biotechnology, Faculty of Chemistry, Warsaw University of Technology, Warsaw, Poland; 3Department of Preclinical Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Warsaw, Poland; 4Department of Morphological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Warsaw, Poland; 5Faculty of Physics, Warsaw University of Technology, Warsaw, Poland; 6Institute of Pathological Physiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic; 7Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic

Abstract: This study provides a review of the therapeutic potential of graphene dressing scaffolds and mesenchymal stem cells (MSCs) and their synergistic effects with respect to cutaneous wound healing. This study also considers their putative action mechanism based on the antibacterial, immunomodulating, angiogenic, matrix remodeling effects of materials belonging to the graphene family and MSCs during the wound healing process. In addition, this study discusses the cytocompatibility of graphene, its uses as a platform for skin substitutes, the properties it possesses with respect to providing protection against microbial invasion as well as strategies aimed at minimizing the chance of the occurrence of sepsis. MSCs are capable of secreting several factors that exert a therapeutic impact on reparative processes and tissue regeneration. In light of experiments conducted to date, graphene combined with MSCs appears to have the potential to enhance both the wound healing process and infection control at the injury site.

Keywords: graphene, mesenchymal stem cells, wound, healing


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