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The effect of ONCE Renal on minerals and electrolytes in predialysis patients with chronic kidney disease

Authors Satirapoj B, Prapakorn J, Punpanich D, Pongsuparbchon C, Supasyndh O

Received 13 October 2015

Accepted for publication 10 February 2016

Published 5 April 2016 Volume 2016:9 Pages 81—86

DOI https://doi.org/10.2147/IJNRD.S98179

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Rabi Yacoub

Peer reviewer comments 3

Editor who approved publication: Professor Pravin Singhal


Bancha Satirapoj,1 Janjira Prapakorn,2 Dollapas Punpanich,2 Chantima Pongsuparbchon,3 Ouppatham Supasyndh1

1Division of Nephrology, Department of Medicine, 2Research Unit, Department of Medicine, 3Clinical Research Center, Phramongkutklao Hospital, Phramongkutklao College of Medicine, Bangkok, Thailand

Background: Malnutrition is one common adverse consequence in patients with advanced chronic kidney disease (CKD), and most patients have a lower-than-normal dietary energy intake. The present study was undertaken to examine whether orally administered ONCE Renal formula (ORF) supplement would improve energy intake without minerals and electrolytes disturbances in predialysis patients with CKD.
Methods: All eligible nondiabetic patients with CKD received ORF supplement for 1 week. Nutrition markers, renal function, and minerals and electrolytes were evaluated before and after supplementing. All patients kept a 3-day food record and were interviewed by a registered dietitian.
Results: A total of 29 patients with mean age 64.9±13.3 years were included. Mean estimated glomerular filtration rate was 37.7±12.1 mL/min/1.73 m2. A significant increase was observed in amount of energy, fat, fiber, calcium, and magnesium intake after 1 week of ORF supplement. Moreover, in comparison with baseline values, the patients displayed decreased dietary protein intake and blood urea nitrogen and increased serum magnesium. However, no significant change was found in renal function, nutritional markers (body weight, prealbumin, albumin, and protein equivalence of total nitrogen appearance), serum calcium, phosphorus, sodium, potassium, and bicarbonate.
Conclusion: In patients with CKD, ingestion of ORF was well tolerated and had a positive effect with an increase in dietary energy, fat, and fiber intake, as well as a decreased dietary protein intake. No mineral or electrolyte abnormalities were observed during the study.

Keywords: oral-specific renal nutrition, malnutrition, chronic kidney disease

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