Back to Browse Journals » International Journal of Nanomedicine » Volume 5

The effect of magnetic nanoparticles of Fe3O4 on immune function in normal ICR mice

Authors Bao-An Chen, Nan Jin, Jun Wang, et al

Published 10 August 2010 Volume 2010:5 Pages 593—599

DOI https://dx.doi.org/10.2147/IJN.S12162

Review by Single-blind

Peer reviewer comments 4

Bao-An Chen1, Nan Jin1, Jun Wang1, Jiahua Ding1, Chong Gao1, Jian Cheng1, Guohua Xia1, Feng Gao1, Yin Zhou1, Yue Chen1, Guina Zhou1, Xiaomao Li2, Yu Zhang3, Men Tang3, Xuemei Wang3

1Department of Hematology, Zhongda Hospital, Clinical Medical School, Southeast University, Nanjing, People’s Republic of China; 2Department of Physics, University of Saarland, D-266041 Saarbruechen, Germany; 3National Key Laboratory of Bioelectronics (Chien-Shiung Wu Laboratory), Southeast University, Nanjing, People’s Republic of China

Abstract: We investigated the effect of magnetic nanoparticles of Fe3O4 (Fe3O4-MNPs) on the mice immune system. Imprinting control region (ICR) mice were assigned randomly into four groups and treated with normal saline or low, medium, or high doses of Fe3O4-MNPs, respectively. After intravenous administration of Fe3O4-MNPs for 72 hours, the peripheral T cells and the induction of primary immune responses in mice were investigated by flow cytometry and determined using enzyme-linked immunosorbent assay, respectively. The results showed that the ratio of spleen to body weight was not different between the experimental groups and control group (P > 0.05). The lymphocyte transformation rates in the suspension of spleen were higher in low-dose group than those in the control group (P < 0.05), while the proliferation of splenocytes was low in the medium and high groups when compared to the control group (P < 0.05). In peripheral blood, both the proportions of subset CD4+ and CD8+ T lymphocytes in the low-dose group were higher than those in the control group, whereas there was no difference in the number of CD4+ T cells between the medium- and low-dose groups. Interestingly, the Fe3O4-MNPs enhanced the production of interleukin-2 (IL-2), interferon-γ, and IL-10 but did not affect the production of IL-4 in peripheral blood. It is concluded that Fe3O4-MNPs could influence immune functions of normal ICR mice in a dose-dependent manner.

Keywords: magnetic nanoparticle of Fe3O4, immune function, splenocyte proliferation, cytokine

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF] 

 

Other articles by this author:

Effects of magnetic nanoparticles of Fe3O4 combinated with gambogic acid on apoptosis of SMMC-7721 cells

Tian L, Chen BA, Cheng J, Guo QL

OncoTargets and Therapy 2015, 8:2285-2290

Published Date: 26 August 2015

Reversal of multidrug resistance by cisplatin-loaded magnetic Fe3O4 nanoparticles in A549/DDP lung cancer cells in vitro and in vivo

Li K, Chen B, Xu L, Feng J, Xia G, Cheng J, Wang J, Gao F, Wang X

International Journal of Nanomedicine 2013, 8:1867-1877

Published Date: 9 May 2013

Synergistic effect of a combination of nanoparticulate Fe3O4 and gambogic acid on phosphatidylinositol 3-kinase/Akt/Bad pathway of LOVO cells

Fang L, Chen B, Liu S, Wang R, Hu S, Xia G, Tian Y, Cai X

International Journal of Nanomedicine 2012, 7:4109-4118

Published Date: 30 July 2012

Effect of magnetic nanoparticles of Fe3O4 and wogonin on the reversal of multidrug resistance in K562/A02 cell line

Cheng J, Cheng L, Chen B, Xia G, Gao C, Song H, Bao W, Guo Q, Zhang H, Wang X

International Journal of Nanomedicine 2012, 7:2843-2852

Published Date: 8 June 2012

Multifunctional magnetic Fe3O4 nanoparticles combined with chemotherapy and hyperthermia to overcome multidrug resistance

Ren Y, Zhang H, Chen B, Cheng J, Cai X, Liu R, Xia G, Wu W, Wang S, Ding J, Gao C, Wang J, Bao W, Wang L, Tian L, Song H, Wang X

International Journal of Nanomedicine 2012, 7:2261-2269

Published Date: 3 May 2012

Effect of magnetic nanoparticles on apoptosis and cell cycle induced by wogonin in Raji cells

Wang L, Zhang HJ, Chen BA, Xia GH, Wang S, Cheng J, Shao Z, Gao C, Bao W, Tian L, Ren YY, Xu PP, Cai XH, Liu R, Wang XM

International Journal of Nanomedicine 2012, 7:789-798

Published Date: 14 February 2012

Daunorubicin-TiO2 nanocomposites as a “smart” pH-responsive drug delivery system

Zhang H, Wang C, Chen B, Wang X

International Journal of Nanomedicine 2012, 7:235-242

Published Date: 12 January 2012

Prevention of acute graft-versus-host disease by magnetic nanoparticles of Fe3O4 combined with cyclosporin A in murine models

Cheng J, Zhou Y, Chen B, Wang J, Xia G, Jin N, Ding J, Gao C, Chen G, Miao Y, Li W, Liu Z, Wang X

International Journal of Nanomedicine 2011, 6:2183-2189

Published Date: 3 October 2011

A promising strategy for overcoming MDR in tumor by magnetic iron oxide nanoparticles co-loaded with daunorubicin and 5-bromotetrandrin

Cheng J, Wang J, Chen BA, Xia GH, Cai XH, Liu R, Ren YY, Bao W, Wang XM

International Journal of Nanomedicine 2011, 6:2123-2131

Published Date: 27 September 2011

Study of the enhanced anticancer efficacy of gambogic acid on Capan-1 pancreatic cancer cells when mediated via magnetic Fe3O4 nanoparticles

Wang C, Zhang H, Chen B, Yin H, Wang W

International Journal of Nanomedicine 2011, 6:1929-1935

Published Date: 9 September 2011

Effect of magnetic Fe3O4 nanoparticles with 2-methoxyestradiol on the cell-cycle progression and apoptosis of myelodysplastic syndrome cells

Xia G, Chen B, Ding J, Gao C, Lu H, Shao Z, Gao F, Wang X

International Journal of Nanomedicine 2011, 6:1921-1927

Published Date: 8 September 2011

Effect of interaction of magnetic nanoparticles of Fe3O4 and artesunate on apoptosis of K562 cells

Wang Y, Han Y, Yang Y, Yang J, Guo X, Zhang J, Pan L, Xia G, Chen B

International Journal of Nanomedicine 2011, 6:1185-1192

Published Date: 9 June 2011

Apoptotic mechanism of human leukemia K562/A02 cells induced by magnetic iron oxide nanoparticles co-loaded with daunorubicin and 5-bromotetrandrin

Wang J, Chen B, Cheng J, Cai X, Xia G, Liu R, Wang X

International Journal of Nanomedicine 2011, 6:1027-1034

Published Date: 17 May 2011

The changes of T lymphocytes and cytokines in ICR mice fed with Fe3O4 magnetic nanoparticles

Wang J, Chen B, Jin N, Xia G, Chen Y, Zhou Y, Cai X, Ding J, Li X, Wang X

International Journal of Nanomedicine 2011, 6:605-610

Published Date: 1 April 2011

Synthesis and antitumor efficacy of daunorubicin-loaded magnetic nanoparticles

Jun Wang, Baoan Chen, Jian Chen, et al

International Journal of Nanomedicine 2011, 6:203-211

Published Date: 24 January 2011

Biocompatibility of Fe3O4/DNR magnetic nanoparticles in the treatment of hematologic malignancies

Weiwei Wu, Baoan Chen, Jian Cheng, et al

International Journal of Nanomedicine 2010, 5:1079-1084

Published Date: 2 December 2010

Magnetic Fe3O4 nanoparticles and chemotherapy agents interact synergistically to induce apoptosis in lymphoma cells

Hongmei Jing, Jing Wang, Ping Yang, et al

International Journal of Nanomedicine 2010, 5:999-1004

Published Date: 19 November 2010

Pharmacokinetic parameters and tissue distribution of magnetic Fe3O4 nanoparticles in mice

Jun Wang, Yue Chen, Baoan Chen, et al

International Journal of Nanomedicine 2010, 5:861-866

Published Date: 13 October 2010

Effect of Fe3O4-magnetic nanoparticles on acute exercise enhanced KCNQ1 expression in mouse cardiac muscle

Lijie Liu, Baoan Chen,Feixiang Teng, et al

International Journal of Nanomedicine 2010, 5:109-116

Published Date: 25 February 2010

Synergistic effect of magnetic nanoparticles of Fe3O4 with gambogic acid on apoptosis of K562 leukemia cells

Baoan Chen, Yiqiong Liang, Weiwei Wu, et al

International Journal of Nanomedicine 2009, 4:251-259

Published Date: 10 November 2009

Effect of magnetic nanoparticles of Fe3O4 and 5-bromotetrandrine on reversal of multidrug resistance in K562/A02 leukemic cells

Jian Cheng, Weiwei Wu, Bao-an Chen, et al

International Journal of Nanomedicine 2009, 4:209-216

Published Date: 30 September 2009

Daunorubicin-loaded magnetic nanoparticles of Fe3O4 overcome multidrug resistance and induce apoptosis of K562-n/VCR cells in vivo

Bao-an Chen, Bin-bin Lai, Jian Cheng, et al

International Journal of Nanomedicine 2009, 4:201-208

Published Date: 23 September 2009

The reversal effect of magnetic Fe3O4 nanoparticles loaded with cisplatin on SKOV3/DDP ovarian carcinoma cells

Zhi Jiang, Bao-An Chen, Guo-Hua Xia, Qiang Wu, et al.

International Journal of Nanomedicine 2009, 4:107-114

Published Date: 30 April 2009

Reversal of multidrug resistance by magnetic Fe3O4 nanoparticle copolymerizating daunorubicin and 5-bromotetrandrine in xenograft nude-mice

Baoan Chen, Jian Cheng, Yanan Wu, Feng Gao, Wenlin Xu, et al

International Journal of Nanomedicine 2009, 4:73-78

Published Date: 18 March 2009

Synergistic effect of the combination of nanoparticulate Fe3O4 and Au with daunomycin on K562/A02 cells

Bao-An Chen, Yong-Yuan Dai, Xue-Mei Wang, Ren-Yun Zhang, Wen-Lin Xu, et al

International Journal of Nanomedicine 2008, 3:343-350

Published Date: 12 September 2008

Readers of this article also read:

Is increasing the dose of Entecavir effective in partial virological responders?

Erturk A, Adnan Akdogan R, Parlak E, Cure E, Cumhur Cure M, Ozturk C

Drug Design, Development and Therapy 2014, 8:621-625

Published Date: 29 May 2014

Methacrylic-based nanogels for the pH-sensitive delivery of 5-Fluorouracil in the colon

Ashwanikumar N, Kumar NA, Nair SA, Kumar GS

International Journal of Nanomedicine 2012, 7:5769-5779

Published Date: 15 November 2012

Cross-linked acrylic hydrogel for the controlled delivery of hydrophobic drugs in cancer therapy

Deepa G, Thulasidasan AK, Anto RJ, Pillai JJ, Kumar GS

International Journal of Nanomedicine 2012, 7:4077-4088

Published Date: 27 July 2012

Daunorubicin-TiO2 nanocomposites as a “smart” pH-responsive drug delivery system

Zhang H, Wang C, Chen B, Wang X

International Journal of Nanomedicine 2012, 7:235-242

Published Date: 12 January 2012

Systematic in-vitro evaluation of the NCI/NIH Developmental Therapeutics Program Approved Oncology Drug Set for the identification of a candidate drug repertoire for MLL-rearranged leukemia

Hoeksema KA, Jayanthan A, Cooper T, Gore L, Trippett T, Boklan J, Arceci RJ, Narendran A

OncoTargets and Therapy 2011, 4:149-168

Published Date: 5 September 2011

Particle size reduction to the nanometer range: a promising approach to improve buccal absorption of poorly water-soluble drugs

Rao S, Song Y, Peddie F, Evans AM

International Journal of Nanomedicine 2011, 6:1245-1251

Published Date: 20 June 2011

Current and developing therapeutic agents in the treatment of Chagas disease

Werner Apt

Drug Design, Development and Therapy 2010, 4:243-253

Published Date: 17 September 2010

Synergistic effect of magnetic nanoparticles of Fe3O4 with gambogic acid on apoptosis of K562 leukemia cells

Baoan Chen, Yiqiong Liang, Weiwei Wu, et al

International Journal of Nanomedicine 2009, 4:251-259

Published Date: 10 November 2009