The effect of CyberKnife therapy on pulmonary function tests used for treating non-small cell lung cancer: a retrospective, observational cohort pilot study

Rishi Agarwal,^1,2 Paramveer Saluja,¹ Angela Pham,³ Karen Ledbetter,³ Sukhveer Bains,³ Seema Varghese,³ John Clements,¹ Young H Kim<sup>4

1</sup>Synergy Medical Education Alliance, Michigan State University College of Human Medicine, Saginaw, Michigan, USA; ²MD Anderson Cancer Center, Houston, Texas, USA; ³Michigan State University, Saginaw, Michigan, USA; ⁴Seton Cancer Institute, Saginaw, Michigan, USA

Introduction: The current standard for treating operable early stage non-small cell lung cancer is surgical resection and for inoperable cases it is external beam radiotherapy. Lung functions are adversely affected with both the above treatments. CyberKnife treatment limits radiation damage by tracking targets moving with each breath. The effect of CyberKnife treatment on pulmonary function tests has not been well documented.
Methods: Lung cancer patients who underwent CyberKnife treatment and had pre- and post-treatment pulmonary function tests were included. Paired t-tests were conducted. We also conducted subgroup analysis.
Results : Thirty-seven patients were included. Median age was 73 years. No statistical difference between mean pre- and post-CyberKnife pulmonary function tests was found.
Discussion: We observed that CyberKnife better preserves lung function status compared to current standards of care. It has shown to have very minimal side effects.

Keywords: non-small cell lung cancer, radiation pneumonitis, radiotherapy, pulmonary function tests