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The complex regulation of TGF-ß in cardiovascular disease

Authors Redondo S, Navarro-Dorado J, Ramajo M, Medina Ú, Tejerina T

Received 14 July 2012

Accepted for publication 15 August 2012

Published 13 September 2012 Volume 2012:8 Pages 533—539

DOI https://doi.org/10.2147/VHRM.S28041

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Santiago Redondo, Jorge Navarro-Dorado, Marta Ramajo, Úrsula Medina, Teresa Tejerina

Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain

Abstract: Transforming growth factor β (TGF-β1) is a pleiotropic cytokine with many and complex effects in cell and tissue physiology. This is made possible by a very complex and interwoven signaling system, whose regulation continues to be the focus of a growing line of research. This complex regulation translates to a key role in cardiovascular physiology, hemostasis, and the blood–vessel interface. In accordance with this, the TGF-β1 pathway appears to be deregulated in related disorders, such as atherosclerotic vascular disease and myeloproliferative syndromes. It is expected that the growing amount of experimental and clinical research will yield medical advances in the applications of knowledge of the TGF-β1 pathway to diagnosis and therapeutics.

Keywords: transforming growth factor beta, pathway, Smads, non-Smads, atherosclerosis, myeloproliferative syndromes

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