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The Association Between Subclinical Hypothyroidism and Sleep Quality: A Population-Based Study

Authors Song L, Lei J, Jiang K, Lei Y, Tang Y, Zhu J, Li Z, Tang H

Received 14 October 2019

Accepted for publication 5 December 2019

Published 19 December 2019 Volume 2019:12 Pages 369—374

DOI https://doi.org/10.2147/RMHP.S234552

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Professor Marco Carotenuto


Linlin Song, 1 Jianyong Lei, 1 Ke Jiang, 1 Yali Lei, 2 Yuting Tang, 2 Jingqiang Zhu, 1 Zhihui Li, 1 Huairong Tang 2

1Thyroid and Parathyroid Surgery Center, West China Hospital of Sichuan University, Chengdu 610041, People’s Republic of China; 2Health and Management Center, West China Hospital of Sichuan University, Chengdu 610041, People’s Republic of China

Correspondence: Huairong Tang
Health and Management Center, West China Hospital of Sichuan University, Chengdu 610041, People’s Republic of China
Tel/Fax +86-28-85422933
Email thrhuaxi11@163.com

Background and Aim: The relationship between subclinical hypothyroidism (SHYPO) and sleep quality is still unclear. Our objective was to compare the sleep quality between SHYPO patients and a control group with normal thyroid function.
Methods: A total of 2224 patients with SHYPO and 12,622 euthyroid (EUTH) control group patients were included in the present study. The Pittsburgh Sleep Quality Index (PSQI) was used to assess sleep quality. The sleep outcomes were compared to explore the association between SHYPO and sleep quality. Furthermore, we tried to identify the risk factors of poor sleep in SHYPO patients.
Results: Compared to the EUTH control patients, SHYPO patients had a higher PSQI score (6.83 ± 2.67 vs 6.64 ± 2.63, p =0.004) and a higher proportion of poor sleepers (67.09% vs 64.75%, p =0.033). Moreover, subjects with SHYPO were associated with poorer sleep (Odd Ratio (OR) 1.120, 95% Confidence Intervals (CI) 1.016 to 1.235, p =0.023), longer sleep latency (OR 1.162, 95% CI 1.053 to 1.282, p =0.003), and shorter sleep duration (OR 1.148, 95% CI 1.019 to 1.293, p =0.023) after adjusting for potential confounders. Furthermore, we found that lower age, lower body mass index, and women were risk factors for poor sleep quality in SHYPO patients.
Conclusion: Our findings suggest a relationship between SHYPO and poor sleep quality in a large Chinese population.

Keywords: subclinical hypothyroidism, sleep quality, PSQI

A Letter to the Editor has been published for this article.


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