The association between metabolic syndrome and asymptomatic carotid artery stenosis in menopausal women: a cross-sectional study in a Chinese population
Authors Zhu B, Zhang L, Cheng XP, Wang L, Tian Y, Li XX, Liu YP, Zhao ZG
Received 14 June 2018
Accepted for publication 24 August 2018
Published 2 November 2018 Volume 2018:14 Pages 2183—2188
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Colin Mak
Peer reviewer comments 3
Editor who approved publication: Professor Deyun Wang
Bin Zhu,1 Lei Zhang,2 Xiao Ping Cheng,3 Lei Wang,4 Yue Tian,1 Xi Xi Li,1 Ying Ping Liu,5 Zhi Gang Zhao1
1Department of Pharmacy, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing 100050, China; 2Department of Pharmacy, Beijing Shijitan Hospital, Capital Medical University, Beijing 100050, China; 3Department of Nephrology, Shaanxi Hospital of Traditional Chinese Medical, ShaaXi 710003, China; 4Department of Endocrinology, Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing 100029, China; 5Obstetrics Department, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China
Background: To examine the association of metabolic syndrome (MetS) with carotid artery stenosis (CAS), especially in menopausal women in China.
Materials and methods: A cross-sectional study of menopause women aged ≥40 years were enrolled from the Jidong community of Tangshan City between 2013 and 2014 to examine the association between MetS and CAS. Logistic regression analyses were performed to analyze the association between MetS and the presence of CAS.
Results: A total of 762 menopause women with mean age 59.3±5.6 years were enrolled in our analysis. Of all the people, 111 participants in CAS group (n=159) and 297 participants in no CAS group (n=603) were diagnosed with MetS meantime. Menopausal women with MetS had increased risk of CAS (OR, 2.383; 95% CI, 1.639–3.464), and the association was further verified by adjusting for confounding factors (OR, 1.949; 95% CI, 1.269–2.994). In addition, age, physical activity (never or moderate), body mass index (>24 kg/m2), and family income (<3,000 RMB) were independent important factors to CAS development in those with MetS.
Conclusion: MetS is associated with CAS especially in women after menopause.
Keywords: metabolic syndrome, carotid artery stenosis, cross-sectional study, Jidong community, menopause
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