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The Advances of Ceria Nanoparticles for Biomedical Applications in Orthopaedics

Authors Li H, Xia P, Pan S, Qi Z, Fu C, Yu Z, Kong W, Chang Y, Wang K, Wu D, Yang X

Received 1 July 2020

Accepted for publication 10 August 2020

Published 29 September 2020 Volume 2020:15 Pages 7199—7214

DOI https://doi.org/10.2147/IJN.S270229

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Yan Shen


Hongru Li, Peng Xia, Su Pan, Zhiping Qi, Chuan Fu, Ziyuan Yu, Weijian Kong, Yuxin Chang, Kai Wang, Dankai Wu, Xiaoyu Yang

Department of Orthopedic Surgery, The Second Hospital of Jilin University, Changchun 130041, People’s Republic of China

Correspondence: Dankai Wu; Xiaoyu Yang
Department of Orthopedic Surgery, The Second Hospital of Jilin University, Changchun, TX 130041, People’s Republic of China
Email wudankai@163.com; yangxiaoy@jlu.edu.cn

Abstract: The ongoing biomedical nanotechnology has intrigued increasingly intense interests in cerium oxide nanoparticles, ceria nanoparticles or nano-ceria (CeO2-NPs). Their remarkable vacancy-oxygen defect (VO) facilitates the redox process and catalytic activity. The verification has illustrated that CeO2-NPs, a nanozyme based on inorganic nanoparticles, can achieve the anti-inflammatory effect, cancer resistance, and angiogenesis. Also, they can well complement other materials in tissue engineering (TE). Pertinent to the properties of CeO2-NPs and the pragmatic biosynthesis methods, this review will emphasize the recent application of CeO2-NPs to orthopedic biomedicine, in particular, the bone tissue engineering (BTE). The presentation, assessment, and outlook of the orthopedic potential and shortcomings of CeO2-NPs in this review expect to provide reference values for the future research and development of therapeutic agents based on CeO2-NPs.

Keywords: CeO2-NPs, green synthesis, ROS, bone tissue engineering, coating, orthopedic implants

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