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The 24-hour pulse wave velocity, aortic augmentation index, and central blood pressure in normotensive volunteers

Authors Kuznetsova T, Korneva V, Bryantseva E, Barkan V, Orlov A, Posokhov I, Rogoza A

Received 5 February 2014

Accepted for publication 5 March 2014

Published 28 April 2014 Volume 2014:10 Pages 247—251

DOI https://doi.org/10.2147/VHRM.S61978

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3


Tatyana Y Kuznetsova,1 Viktoria A Korneva,1 Evgeniya N Bryantseva,2 Vitaliy S Barkan,2 Artemy V Orlov,3 Igor N Posokhov,4 Anatoly N Rogoza5

1Faculty of Medicine, Petrozavodsk State University, Petrozavodsk, Russia; 2Diagnostics Department, The hospital within the Russian Railroad Network, Chita, Russia; 3Department 65 Competitive System Analysis, National Research Nuclear University MEPhI, Moscow, Russia; 4Hemodynamic Laboratory Ltd, Nizhniy Novgorod, Russia; 5Cardiology Research Center, Moscow, Russia

Abstract: The purpose of this study was to examine the pulse wave velocity, aortic augmentation index corrected for heart rate 75 (AIx@75), and central systolic and diastolic blood pressure during 24-hour monitoring in normotensive volunteers. Overall, 467 subjects (206 men and 261 women) were recruited in this study. Participants were excluded from the study if they were less than 19 years of age, had blood test abnormalities, had a body mass index greater than 27.5 kg/m2, had impaired glucose tolerance, or had hypotension or hypertension. Ambulatory blood pressure monitoring (ABPM) with the BPLab® device was performed in each subject. ABPM waveforms were analyzed using the special automatic Vasotens® algorithm, which allows the calculation of pulse wave velocity, AIx@75, central systolic and diastolic blood pressure for “24-hour”, “awake”, and “asleep” periods. Circadian rhythms and sex differences in these indexes were identified. Pending further validation in prospective outcome-based studies, our data may be used as preliminary diagnostic values for the BPLab ABPM additional index in adult subjects.

Keywords: ambulatory, monitoring, arterial stiffness, augmentation index, central blood pressure, reference values

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