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Temporary diplopia upon hyoscine-N-butyl bromide administration: case report

Authors Migliorini R, Malagola R, Mafrici M, Spena R, Arrico L

Received 5 February 2013

Accepted for publication 10 April 2013

Published 23 May 2013 Volume 2013:7 Pages 947—949

DOI https://doi.org/10.2147/OPTH.S43680

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2


R Migliorini, R Malagola, M Mafrici, R Spena, L Arrico

Department of Sense Organs, University of Rome "La Sapienza", Rome, Italy

Abstract: Hyoscine-N-butyl bromide is a widely used antispasmodic belonging to the belladonna alkaloid class of semisynthetic quaternary ammonium compounds. These compounds exert a spasmolytic action on the smooth muscles of the bile-gastrointestinal tract, genitourinary tract, salivary glands (xerostomia), and also on the visual apparatus – in particular, the irido-ciliary complex. As a consequence, they provoke collateral effects such as mydriasis and accommodation disturbances. We report the case of a 23-year-old woman who complained of not only "dry mouth" but also "cloudy vision" and a "diplopia", both of temporary type, 2 hours after oral administration of hyoscine-N-butyl bromide.

Keywords: hyoscine-N-butyl bromide, accommodation disorders, temporary diplopia, fusion alteration, vertical strabismus

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