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Targeting prostate cancer cells with hybrid elastin-like polypeptide/liposome nanoparticles

Authors Zhang W, Song Y, Eldi P, Guo X, Hayball JD, Garg S, Albrecht H

Received 28 September 2017

Accepted for publication 21 November 2017

Published 9 January 2018 Volume 2018:13 Pages 293—305

DOI https://doi.org/10.2147/IJN.S152485

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Alexander Kharlamov

Peer reviewer comments 2

Editor who approved publication: Dr Thomas Webster


Wei Zhang,1 Yunmei Song,1 Preethi Eldi,1 Xiuli Guo,2 John D Hayball,1,3 Sanjay Garg,1 Hugo Albrecht1

1Centre for Pharmaceutical Innovation and Development, Centre for Drug Discovery and Development, Experimental Therapeutics Laboratory, Sansom Institute for Health Research, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA, Australia; 2Department of Pharmacology, School of Pharmaceutical Sciences, Shandong University, Jinan, China; 3Robinson Research Institute and Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia

Abstract: Prostate cancer cells frequently overexpress the gastrin-releasing peptide receptor, and various strategies have been applied in preclinical settings to target this receptor for the specific delivery of anticancer compounds. Recently, elastin-like polypeptide (ELP)-based self-assembling micelles with tethered GRP on the surface have been suggested to actively target prostate cancer cells. Poorly soluble chemotherapeutics such as docetaxel (DTX) can be loaded into the hydrophobic cores of ELP micelles, but only limited drug retention times have been achieved. Herein, we report the generation of hybrid ELP/liposome nanoparticles which self-assembled rapidly in response to temperature change, encapsulated DTX at high concentrations with slow release, displayed the GRP ligand on the surface, and specifically bound to GRP receptor expressing PC-3 cells as demonstrated by flow cytometry. This novel type of drug nanocarrier was successfully used to reduce cell viability of prostate cancer cells in vitro through the specific delivery of DTX.

Keywords: ELP-GRP, micelle, liposome, docetaxel, prostate cancer, GRPR, GPCR

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