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Targeting 20-HETE producing enzymes in cancer – rationale, pharmacology, and clinical potential

Authors Alexanian A, Sorokin A

Received 11 December 2012

Accepted for publication 17 February 2013

Published 26 March 2013 Volume 2013:6 Pages 243—255


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Anna Alexanian, Andrey Sorokin

Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA

Abstract: Studies demonstrate that lipid mediator 20-Hydroxyeicosatetraenoic acid (20-HETE) synthesis and signaling are associated with the growth of cancer cells in vitro and in vivo. Stable 20-HETE agonists promote the proliferation of cancer cells, whereas selective inhibitors of the 20-HETE-producing enzymes of the Cytochrome (CYP450)4A and CYP4F families can block the proliferation of glioblastoma, prostate, renal cell carcinoma, and breast cancer cell lines. A recent observation that the expression of CYP4A/4F genes was markedly elevated in thyroid, breast, colon, and ovarian cancer further highlights the significance of 20-HETE-producing enzymes in the progression of different types of human cancer. These findings provide the rationale for targeting 20-HETE-producing enzymes in human cancers and set the basis for the development of novel therapeutic strategies for anticancer treatment.

Keywords: 20-hydroxyeicosatetraenoic acid, CYP4A, CYP4F, HET0016, eicosanoids

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