Back to Journals » International Journal of Nanomedicine » Volume 8 » Issue 1

Targeted hyperthermia after selective embolization with ferromagnetic nanoparticles in a VX2 rabbit liver tumor model

Authors Sun HL, Xu LF, Fan TY, Zhang HZ, Wang XD, Zhou YF, Yang RJ

Received 23 June 2013

Accepted for publication 9 August 2013

Published 2 October 2013 Volume 2013:8(1) Pages 3795—3804

DOI https://doi.org/10.2147/IJN.S50373

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Hongliang Sun,1 Linfeng Xu,1 Tianyuan Fan,2 Hongzhi Zhan,3 Xiaodong Wang,3 Yanfei Zhou,2 Ren-jie Yang3

1Department of Interventional Therapy, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, 2Pharmacy School of Beijing University, Beijing, 3Department of Interventional Therapy, Peking University School of Oncology, Beijing Cancer Hospital and Institute, Beijing, People's Republic of China

Background: The purpose of this study was to observe the effect and feasibility of hyperthermia and the influence of heat on surrounding organs in a VX2 rabbit liver model exposed to an alternating magnetic field after embolization with ferromagnetic nanoparticles.
Methods: Forty rabbits containing implanted hepatic VX2 carcinomas were divided into four groups, each containing ten rabbits. Fourteen days after tumor transplantation, we opened the abdomen to observe the size and shape of the tumor. A transfemoral retrograde approach was then used for hepatic arterial catheterization in groups B, C, and D to perform angiography and embolization. The next day, three rabbits in group B and all rabbits in group D were exposed to an alternating magnetic field, and the temperature was recorded simultaneously in the center of the tumor, at the edge of the tumor, and in the normal liver parenchyma. On day 28, all animals was euthanized to observe changes in the implanted liver tumor and the condition of the abdomen. A pathologic examination was also done.
Results: Before surgery, there was no significant difference in tumor volume between the four groups. Three different temperature points (center of the tumor, edge of the tumor, and in the normal liver parenchyma) of group B under an alternating magnetic field were 37.2°C ± 1.1°C, 36.8°C ± 1.2°C, and 36.9°C ± 2.1°C, none of which were significantly different from pretreatment values. Three points basal temperature in group D showed no significant difference (F = 1.038, P = 0.413). Seven to 26 minutes after hyperthermia, the temperature at the center of the tumor and at the edge of the tumor in group D was significantly different from the corresponding points in group B and from normal liver tissue in group D (FB–D center = 5.431, PB–D center = 0.041, FB–D edge = 9.744, PB–D edge = 0.011; FD = 8.379, PD = 0.002). The highest temperature recorded at the rim of the tumor was 46°C in group D. Fourteen days later, the tumor volume in the four groups was group A 31.4 ± 20.6 cm3, group B 26.7 ± 18.2 cm3, group C 28.7 ± 9.1 cm3, and group D 25.8 ± 13.9 cm3, with no significant difference found between the groups (F = 0.218, P = 0.883). The increase in tumor volume was greatest in group A and least in group D, while that in groups B and D was similar.
Conclusion: It is feasible to treat a VX2 tumor in an alternating magnetic field after embolization with magnetic nanoparticles without a significant effect on the surrounding normal liver parenchyma.

Keywords:
hyperthermia, ferromagnetic nanoparticles, Lipiodol®, hepatocellular carcinoma, animal model


Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]

 

Other article by this author:

The effect of lipiodol deposition in HCC after TACE on the necrosis range of PMCT

Sun HL, Ni JY, Jiang XY, Chen D, Chen YT, Xu LF

OncoTargets and Therapy 2017, 10:3835-3842

Published Date: 1 August 2017

Readers of this article also read:

Variability in contrast agent uptake by different but similar stem cell types

Ketkar-Atre A, Struys T, Soenen SJ, Lambrichts I, Verfaillie CM, De Cuyper M, Himmelreich U

International Journal of Nanomedicine 2013, 8:4577-4591

Published Date: 29 November 2013

Synthesis, characterization, and antimicrobial properties of copper nanoparticles

Usman MS, El Zowalaty ME, Shameli K, Zainuddin N, Salama M, Ibrahim NA

International Journal of Nanomedicine 2013, 8:4467-4479

Published Date: 21 November 2013

The impact of PEGylation patterns on the in vivo biodistribution of mixed shell micelles

Gao H, Liu J, Yang C, Cheng T, Chu L, Xu H, Meng A, Fan S, Shi L, Liu J

International Journal of Nanomedicine 2013, 8:4229-4246

Published Date: 5 November 2013

Branched polyethylenimine-grafted-carboxymethyl chitosan copolymer enhances the delivery of pDNA or siRNA in vitro and in vivo

Park SC, Nam JP, Kim YM, Kim JH, Nah JW, Jang MK

International Journal of Nanomedicine 2013, 8:3663-3677

Published Date: 26 September 2013

Biodistribution, kinetics, and biological fate of SPION microbubbles in the rat

Barrefelt A, Saghafian M, Kuiper R, Ye F, Egri G, Klickermann M, Brismar TB, Aspelin P, Muhammed M, Dähne L, Hassan M

International Journal of Nanomedicine 2013, 8:3241-3254

Published Date: 26 August 2013

Intravenous magnetic nanoparticle cancer hyperthermia

Huang HS, Hainfeld JF

International Journal of Nanomedicine 2013, 8:2521-2532

Published Date: 17 July 2013

Synthesis of talc/Fe3O4 magnetic nanocomposites using chemical co-precipitation method

Kalantari K, Bin Ahmad M, Shameli K, Khandanlou R

International Journal of Nanomedicine 2013, 8:1817-1823

Published Date: 15 May 2013

Preparation and characterization of flexible nanoliposomes loaded with daptomycin, a novel antibiotic, for topical skin therapy

Li C, Zhang X, Huang X, Wang X, Liao G, Chen Z

International Journal of Nanomedicine 2013, 8:1285-1292

Published Date: 24 March 2013

Gemcitabine-loaded liposomes: rationale, potentialities and future perspectives

Federico C, Morittu VM, Britti D, Trapasso E, Cosco D

International Journal of Nanomedicine 2012, 7:5423-5436

Published Date: 1 November 2012

Running a marathon from -45°C to +55°C in a climate chamber: a case study

Kälin K, Knechtle B, Rüst CA, Mydlak K, Rosemann T

Open Access Journal of Sports Medicine 2012, 3:131-145

Published Date: 25 October 2012