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Successful salvage therapy of Fusarium endophthalmitis secondary to keratitis: an interventional case series

Authors Comer G, Stem MS, Saxe SJ

Received 10 March 2012

Accepted for publication 23 March 2012

Published 9 May 2012 Volume 2012:6 Pages 721—726


Review by Single anonymous peer review

Peer reviewer comments 4

Supplementary intraoperative video capturing abscess removal

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Grant M Comer, Maxwell S Stem, Stephen J Saxe

University of Michigan, Department of Ophthalmology and Visual Sciences, Ann Arbor, MI, USA

Purpose: To describe a combination of treatment modalities used for the successful eradication of Fusarium endophthalmitis.
Design: Interventional case series.
Participants: Three consecutive patients with keratitis-associated Fusarium endophthalmitis.
Methods: After failure of traditional management options, a combination of intravitreal and long-term, high-dose systemic voriconazole, topical antifungal medications, and surgical intervention, with penetrating keratoplasty, lensectomy, and endoscopic-guided pars plana vitrectomy, was administered to each patient.
Results: All three cases achieved full resolution of the infection, with a final Snellen visual acuity score of 20/50 to 20/70.
Conclusions: An aggressive combination of therapeutic modalities, including the removal of subiris abscesses, might be needed for the successful resolution of Fusarium endophthalmitis.

Keywords: endophthalmitis, fungal, Fusarium, keratitis, keratoplasty, voriconazole

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