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Successful reversal of isolated delayed spinal cord ischemia following endovascular abdominal aneurysm repair

Authors Aljarrah Q, Al-Omari MH, Elheis M, Al-Jarrah M, Jamal A, Alzoubi A

Received 17 October 2018

Accepted for publication 6 March 2019

Published 23 April 2019 Volume 2019:15 Pages 81—87

DOI https://doi.org/10.2147/VHRM.S191197

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Prof. Dr. Bojan Jelaković

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Qusai Aljarrah,1 Mamoon H Al-Omari,2 Mwaffaq Elheis,2 Mooath Al-Jarrah,3 Abdelwahab Jamal,3 Abdullah Alzoubi4

1Department of Surgery, Faculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan; 2Department of Diagnostic and Interventional Radiology, Faculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan; 3School of Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan; 4Department of Pharmacology, Faculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordon

Abstract: A 74-year-old patient presented with isolated fecal incontinence 6 weeks following endovascular aneurysm repair. The delayed presentation of spinal cord ischemia was precipitated by commencement of alpha-blockers for benign prostatic hyperplasia. This case stresses that vulnerability to spinal cord perfusion is not limited to the perioperative period. In addition, systemic arterial pressure should be closely monitored in cases of marginal vascular insufficiency of the spinal cord.

Keywords: abdominal aortic aneurysm, endovascular aneurysm repair, spinal cord ischemia, fecal incontinence

Introduction

Spinal cord ischemia (SCI) remains a rare, but devastating complication following abdominal aortic aneurysm (AAA) repair. Understanding of the complex pathophysiology of SCI is evolving, but the inciting factors behind many cases remain unidentified. We herein report a case of delayed fecal incontinence due to SCI following EVAR, successfully treated with complete resolution of the patient’s symptoms. Our case suggests that vulnerability to spinal cord perfusion is not limited to the perioperative period, but persists following patient discharge, and that vigilant attention to systemic arterial pressure is crucial in cases of marginal vascular insufficiency of the spinal cord.

Case report

A 74-year-old male patient presented to our hospital with isolated fecal incontinence and loose stool 6 weeks following EVAR. The patient had a notable history of coronary heart disease, previous coronary artery bypass surgery, dyslipidemia, and a history of ulcerative colitis. He was initially referred to our vascular service by the neurosurgery team after a lumbar magnetic resonance imaging (MRI), performed to investigate lower back pain, revealed a large AAA. The MRI also revealed multiple degenerative intervertebral disc bulges in the L2-S1 segments, with significant secondary spinal canal stenosis (Figure 1).

Figure 1 Lumbar Spine MRI: (A) sagittal T2WI showing degenerative disc changes with significant thecal sac compression at levels L5-S1, Magnification X1 (B) axial T2W at levels L4-L5 showing a massive AAA, Magnification X2.Abbreviations: AAA, Abdominal Aortic Aneurysm; MRI, Magantic Resonance Imaging.

Initial vascular assessment revealed an expansile pulsation in the epigastric region associated with mild tenderness and a prominent pulsation in the right iliac fossa. Peripheral vascular examination was otherwise unremarkable.

A computed tomography angiogram (CTA) revealed a 10 cm infrarenal inflammatory AAA, a 3 cm aneurysmal right common iliac artery, and an ectatic 2 cm left common iliac artery. He was found to have a favorable aortic neck anatomy, and a sufficient landing zone (Figure 2). The patient underwent urgent EVAR with a Medtronic Endurant device (Medtronic Vascular, Santa Rosa, CA, USA). We selectively embolized the right internal iliac artery, and intentionally covered both internal iliac arteries due to the features seen on the CTA (Figure 3).

Figure 2 Preoperative CTA: (A) axial view showing a thick-walled 10 cm infrarenal AAA, Magnification x1(B and C) Axial (Magnification X1) and coronal (Magnification X2) views showing an aneurysmal extension into to right IIA.Abbreviations: AAA, Abdominal Aortic Aneurysm; CTA, Computed Tomography Angiography.

Figure 3 Intraoperative digital subtraction angiogram: (A) large infrarenal AAA with aneurysmal dilatation of right common iliac artery and short ectatic left common iliac artery, Magnification X1(B) successful deployment of the bifurcated graft and embolization of RIIA, Magnification X1.Abbreviations: AAA, Abdominal Aortic Aneurysm; RIIA, Right Internal Iliac Artery.

The patient’s postoperative course was uneventful, leading to his discharge on postoperative day three. Two weeks later, he was seen in the outpatient clinic and was found to be recovering adequately with sufficiently healing wounds. Furthermore, a CTA 4-week postoperation showed complete exclusion of the aneurysm without endoleak, as well as maintenance of pelvic perfusion via retrograde flow from the left internal iliac artery (Figure 4).

Figure 4 Follow-up CTA showing: (A) patent graft with exclusion of the aneurysm from circulation and without endoleak, Magnification X1. (B) Retrograde flow into RIIA, Magnification X1.Abbreviations: CTA, Computed Tomography Angiography; RIIA, Right Internal Iliac Artery

Six weeks post-EVAR, the patient experienced an episode of urinary retention due to obstructive uropathy (secondary to benign prostatic hyperplasia), for which he was prescribed Alfuzosin. Following initiation of Alfuzosin, the patient began having dizzy spells and postural hypotension. Two weeks later, he began complaining of loose stool and fecal incontinence, at which time he presented to the vascular clinic.

On clinical evaluation, the patient was hypotensive, with a blood pressure (BP) of 77/44 mmHg. Digital rectal exam (DRE) revealed laxity of the anal sphincter and soft stool, without blood or mucus. A neurological exam indicated 5/5 power in both lower extremities, intact deep tendon reflex, and unremarkable sensory examination. An urgent colonoscopy revealed mild inflammation in the rectum, with a biopsy showing features of ischemic colitis (Figure 5). We consulted the neuromedicine team, who suggested the possibility of isolated SCI, and advised a new lumbosacral spine MRI. This MRI showed no evidence of acute ischemia, and no changes when compared to his initial scan.

Figure 5 Ischemic colitis changes seen on a rectal biopsy. Magnification X4

The patient was admitted for 5 days of intensive therapy to improve his BP. He was started on IV fluids, and Alfuzosin was ceased. A daily 16 mg dose of IV dexamethasone was initiated for suspected SCI, as well as loperamide to thicken his stool. After treatment, his BP rose to an average of 110/60 mmHg, and the patient reported significant improvement in sphincter control. Further DREs revealed greatly improved anal tone. Based on these findings, the patient was discharged and prescribed fludrocortisone (0.1 mg/day), clopidogrel (75 mg), aspirin (100 mg), enoxaparin (40 mg), vitamin E, and loperamide (2 mg).

Two weeks following discharge, the patient was seen in the outpatient clinic, where examination showed a normal BP of 115/60 mmHg, complete recovery of sphincter control, and resolution of diarrheal symptoms.

Discussion

SCI is a potentially disastrous complication following EVAR. SCI can either present immediately or in a delayed fashion.1 Neurological deficits can be transient or permanent.2 The reported incidence of SCI following EVAR is marginally less than that following open repair.3 Luckily, the incidence of SCI following aortic pathologies has recently declined, presumably due to the development of advanced endovascular techniques and improved understanding of variables affecting spinal cord circulation.4 In a recent systematic review, Moulakais et al identified 25 cases of SCI following elective EVAR and found that only 15% of the reported cases presented with delayed SCI.1 Additionally, recovery rates remained low, with only 25% of the cohort experiencing complete recovery of neurological deficits.1

The mechanism of SCI appears to be a consequence of multiple complex interactions, and our current understanding is derived from thoracic and thoracoabdominal aortic surgeries. EVAR and open repair result in different mechanisms of SCI, including endovascular exclusion of vital arterial supply to the spinal cord, perioperative hypotensive episodes, and atheroembolization of debris into pelvic circulation following endovascular instrumentation.5,6,7 Three important mechanisms contribute to delayed SCI; reperfusion injury with the flux of inflammatory and neurochemical mediators, spinal cord edema, and lastly arterial hypotension.7,8,9 Recently, Awad et al unveiled the importance of spinal cord edema in the development of SCI, suggesting a multifactorial process of development.10 Our understanding of SCI is continuously evolving and most likely multifactorial.

Understanding the anatomical blood supply to the spinal cord is fundamental for identifying the etiology of SCI. The spinal cord is not only reliant on a key feeding artery, but also on a rich network of collaterals from branches of the subclavian and vertebral arteries proximally, branches of the intercostal and lumbar arteries centrally, and branches of the inferior mesenteric artery, internal iliac artery, and sacral arteries distally.2,11 These important collateral networks can be interrupted or sacrificed by aortic pathology, or the treatment modality used to correct it. Furthermore, spinal cord autoregulation is disrupted when aortic treatment is performed.4 Preoperative CT and MRI scans must be carefully reviewed to identify potential risks of spinal cord arterial compromise, to identify vulnerable patients, and guide the course of treatment.4,11

SCI has an unpredictable clinical presentation with some patients presenting with varying degrees of lower limb paresis or paralysis, accompanied in some cases with fecal and/or urinary incontinence. Nishioka et al reported a case of isolated bladder and rectal incontinence following EVAR, with complete recovery after hyperbaric oxygen therapy.12

The current management of SCI following EVAR is evolving.2,4 Various neuroprotective interventions have contributed to improved neurological outcomes following surgical or endovascular aortic interventions.2,5,9,11,12 Technical and pharmacological measures with favorable outcomes include CSF drainage, staged repairs, iliac branched devices, increasing mean arterial pressure, steroid administration, hyperbaric oxygen, naloxone, papaverine hydrochloride, and barbiturates.

The existing body of literature reported three cases of significantly delayed (>2 weeks) SCI following EVAR: Reid et al reported a delayed, but temporary paraplegia 2 weeks following EVAR,13 Goldstein et al reported a delayed, but permanent paraplegia 3 weeks following EVAR,9 whereas Maddock et al reported a delayed, but reversible hemiparesis 8 weeks following EVAR.7 Interestingly, all three cases demonstrated acute hypoperfusion of the spinal cord secondary to hypotension.

In the present case, the etiology of delayed SCI is likely multifactorial. The patient had significant spinal stenosis, which may worsen spinal perfusion pressure in the presence of reperfusion edema within a confined compartment. Additionally, the patient was prescribed a potent alpha-blocker, which resulted in postural hypotension and reduced mean arterial pressure. The unique delayed presentation of SCI in this patient was precipitated by hemodynamic instability resulting from the use of alpha-blockers in the presence of vulnerable pelvic circulation.

Substantial evidence highlights the importance of maintaining adequate perioperative BP in aortic reconstructions. Safi et al reported that 50% of cases presenting with delayed SCI following thoracoabdominal aneurysm repair had a period of BP instability.14 Melissano et al advocated suspending antihypertensive medications following complex aortic reconstruction to avoid postoperative hypotension and hemodynamic instability.2 Moreover, Scott et al emphasized the importance of maintaining adequate arterial pressure regardless of hospitalization status.11

Our case report highlights the importance of maintaining adequate hemodynamic stability by augmenting arterial BP in cases of marginal pelvic vascular insufficiency. In our case, CSF drainage was avoided because the patient was treated with dual antiplatelet therapy and had significant spinal stenosis. Furthermore, recent evidence suggests internal iliac plugging is preferable to coil embolization if required in EVAR.15

To the best of our knowledge, this is the first reported case of significantly delayed isolated fecal incontinence following EVAR that has been successfully reversed by conservative management.

In conclusion, alpha-blockers are best avoided in cases of marginal vascular insufficiency of the spinal cord following aortic interventions. Vulnerability to SCI is not limited to the perioperative period but persists following patient discharge. Finally, hemodynamic SCI is potentially reversible if managed promptly and efficiently.

Ethics statement and patient consent

Written informed consent was obtained from the patient for publication. Institutional approval was not required.

Abbreviations

SCI, spinal cord ischemia; AAA, abdominal aortic aneurysm; EVAR, endovascular aneurysm repair; HBO, hyperbaric oxygen; DRE, digital rectal examination; BP, blood pressure.

Acknowledgments

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Disclosure

The authors report no conflicts of interest in this work.

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