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Subretinal recombinant tissue plasminogen activator and pneumatic displacement for the management of subretinal hemorrhage occurring after anti-VEGF injections for wet AMD

Authors Tognetto D, Skiadaresi, Cecchini P, Ravalico G

Published 13 April 2011 Volume 2011:5 Pages 459—463

DOI https://doi.org/10.2147/OPTH.S15864

Review by Single-blind

Peer reviewer comments 2


Daniele Tognetto, Eirini Skiadaresi, Paolo Cecchini, Giuseppe Ravalico
Eye Clinic, University of Trieste, Trieste, Italy

Abstract: We describe three cases of submacular hemorrhage that occurred two to four days after anti-VEGF intravitreal injection for occult choroidal neovascularisation in age-related macular degeneration and their management with 25 gauge pars plana vitrectomy with injection of subretinal recombinant tissue plasminogen activator (rTPA) followed by fluid-air exchange and postoperative prone position. Vitrectomy, subretinal rTPA injection and fluid-gas exchange apply as a safe and effective treatment in these cases. Functional results seem to be positive especially if surgical treatment is promptly performed.

Keywords: vitrectomy, rTPA subretinal injection, gas tamponade, blood displacement

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