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Sub-10 nm Cu5FeS4 cube for magnetic resonance imaging-guided photothermal therapy of cancer

Authors Wang D, Zhang Y, Guo Q

Received 21 July 2018

Accepted for publication 23 September 2018

Published 26 November 2018 Volume 2018:13 Pages 7987—7996

DOI https://doi.org/10.2147/IJN.S181056

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Mohankandhasamy Ramasamy

Peer reviewer comments 2

Editor who approved publication: Dr Linlin Sun


Dan Wang,1 Yuwen Zhang,1 Qi Guo2

1Department of Pathology, The First People’s Hospital of Shangqiu, Shangqiu, Henan 476000, China; 2Department of Orthopedics, The First People’s Hospital of Shangqiu, Shangqiu, Henan 476000, China

Background: Facile synthesis and small size theranostic agents have shown great potential for cancer diagnosis and treatment.
Purpose: A ternary compound (Cu5FeS4), Fe doped copper sulfide, with novel magnetic properties and strong near-infrared absorption was prepared for magnetic resonance imaging (MRI) imaging guided photothermal therapy of cancer.
Patients and methods: Firstly, the capability of magnetic resonance imaging based on the novel magnetic properties and the photothermal performance due to the strong near-infrared absorption was investigated in vitro. Then, the magnetic resonance imaging guided photothermal therapy for 4T1 tumor-bearing mouse was carried out.
Results: The Cu5FeS4 cube with good T1-weighted MRI, excellent photothermal performance and low cytotoxicity has been investigated. More importantly, the T1-weighted MRI for 4T1 tumor-bearing mouse will get the best contrast effect at tumor site after 8 h of intravenous injection of Cu5FeS4 cube. Under the guidance of the T1-weighted MRI, the PTT was carried out at 8 h after intravenous injection of Cu5FeS4 cube and only the group combined intravenous administration of Cu5FeS4 cube and laser irradiation nearly cured the tumor after 14 days.
Conclusion: Our study not only provides a new material for personalized treatment of tumors, but also further promotes potential applications of the cancer theranostic agents.

Keywords: magnetic nanoparticle, imaging, theranostic, 4T1, ultra-small

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