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Study of antitumor activity in breast cell lines using silver nanoparticles produced by yeast
Authors Ortega F, Fernández Baldo M, Fernández J, Serrano M, Sanz M, Díaz-Mochón J, Lorente J, Raba J
Received 15 October 2014
Accepted for publication 22 November 2014
Published 16 March 2015 Volume 2015:10(1) Pages 2021—2031
DOI https://doi.org/10.2147/IJN.S75835
Checked for plagiarism Yes
Review by Single-blind
Peer reviewer comments 4
Editor who approved publication: Dr Thomas Webster
Francisco G Ortega,1 Martín A Fernández-Baldo,2 Jorge G Fernández,2 María J Serrano,1 María I Sanz,2 Juan J Diaz-Mochón,1 José A Lorente,1 Julio Raba2
1GENYO, Centre for Genomics and Oncological Research: Pfizer-University of Granada, Andalusian Regional Government, PTS Granada, Avenida de Ilustración, Granada, Spain; 2INQUISAL, Departamento de Química, CONICET, Universidad Nacional de San Luis, San Luis, Argentina
Abstract: In the present article, we describe a study of antitumor activity in breast cell lines using silver nanoparticles (Ag NPs) synthesized by a microbiological method. These Ag NPs were tested for their antitumor activity against MCF7 and T47D cancer cells and MCF10-A normal breast cell line. We analyzed cell viability, apoptosis induction, and endocytosis activity of those cell lines and we observed that the effects of the biosynthesized Ag NPs were directly related with the endocytosis activity. Moreover, Ag NPs had higher inhibition efficacy in tumor lines than in normal lines of breast cells, which is due to the higher endocytic activity of tumor cells compared to normal cells. In this way, we demonstrate that biosynthesized Ag NPs can be an alternative for the treatment of tumors.
Keywords: apoptosis, biosynthesized silver nanoparticles, breast cancer, microbiological synthesis
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