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Study of antitumor activity in breast cell lines using silver nanoparticles produced by yeast

Authors Ortega FG, Fernández-Baldo MA, Fernández JG, Serrano MJ, Sanz MI, Diaz-Mochón JJ, Lorente JA, Raba J

Received 15 October 2014

Accepted for publication 22 November 2014

Published 16 March 2015 Volume 2015:10(1) Pages 2021—2031

DOI https://doi.org/10.2147/IJN.S75835

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Editor who approved publication: Dr Thomas J Webster

Francisco G Ortega,1 Martín A Fernández-Baldo,2 Jorge G Fernández,2 María J Serrano,1 María I Sanz,2 Juan J Diaz-Mochón,1 José A Lorente,1 Julio Raba2

1GENYO, Centre for Genomics and Oncological Research: Pfizer-University of Granada, Andalusian Regional Government, PTS Granada, Avenida de Ilustración, Granada, Spain; 2INQUISAL, Departamento de Química, CONICET, Universidad Nacional de San Luis, San Luis, Argentina


Abstract: In the present article, we describe a study of antitumor activity in breast cell lines using silver nanoparticles (Ag NPs) synthesized by a microbiological method. These Ag NPs were tested for their antitumor activity against MCF7 and T47D cancer cells and MCF10-A normal breast cell line. We analyzed cell viability, apoptosis induction, and endocytosis activity of those cell lines and we observed that the effects of the biosynthesized Ag NPs were directly related with the endocytosis activity. Moreover, Ag NPs had higher inhibition efficacy in tumor lines than in normal lines of breast cells, which is due to the higher endocytic activity of tumor cells compared to normal cells. In this way, we demonstrate that biosynthesized Ag NPs can be an alternative for the treatment of tumors.

Keywords: apoptosis, biosynthesized silver nanoparticles, breast cancer, microbiological synthesis

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