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Stimulus-responsive vesicular polymer nano-integrators for drug and gene delivery

Authors Mu X, Gan S, Wang Y, Li H, Zhou G

Received 30 January 2019

Accepted for publication 8 May 2019

Published 18 July 2019 Volume 2019:14 Pages 5415—5434

DOI https://doi.org/10.2147/IJN.S203555

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Melinda Thomas

Peer reviewer comments 2

Editor who approved publication: Dr Linlin Sun


Xin Mu,1,2 Shenglong Gan,1,2 Yao Wang,1,2 Hao Li,1,2 Guofu Zhou1,2

1Guangdong Provincial Key Laboratory of Optical Information Materials and Technology & Institute of Electronic Paper Displays, South China Academy of Advanced Optoelectronics, South China Normal University, Guangzhou 510006, People’s Republic of China; 2National Center for International Research on Green Optoelectronics, South China Normal University, Guangzhou 510006, People’s Republic of China

Abstract: Over the past two decades, nano-sized biosystems have increasingly been utilized to deliver various pharmaceutical agents to a specific region, organ or tissue for controllable precision therapy. Whether solid nanohydrogel, nanosphere, nanoparticle, nanosheet, micelles and lipoproteins, or “hollow” nanobubble, liposome, nanocapsule, and nanovesicle, all of them can exhibit outstanding loading and releasing capability as a drug vehicle – in particular polymeric nanovesicle, a microscopic hollow sphere that encloses a water core with a thin polymer membrane. Besides excellent stability, toughness and liposome-like compatibility, polymeric nanovesicles offer considerable scope for tailoring properties by changing their chemical structure, block lengths, stimulus-responsiveness and even conjugation with biomolecules. In this review, we summarize the latest advances in stimulus-responsive polymeric nanovesicles for biomedical applications. Different functionalized polymers are in development to construct more complex multiple responsive nanovesicles in delivery systems, medical imaging, biosensors and so on.

Keywords: nanovesicle, stimulus-responsive, amphiphilic block copolymer, self-assembled, drug delivery

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