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Static DNA Nanostructures For Cancer Theranostics: Recent Progress In Design And Applications

Authors Jahanban-Esfahlan R, Seidi K, Jahanban-Esfahlan A, Jaymand M, Alizadeh E, Majdi H, Najjar R, Javaheri T, Zare P

Received 14 August 2019

Accepted for publication 13 September 2019

Published 15 October 2019 Volume 2019:12 Pages 25—46

DOI https://doi.org/10.2147/NSA.S227193

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Melinda Thomas

Peer reviewer comments 2

Editor who approved publication: Professor Israel (Rudi) Rubinstein


Rana Jahanban-Esfahlan,1,2 Khaled Seidi,3 Ali Jahanban-Esfahlan,4 Mehdi Jaymand,5 Effat Alizadeh,1 Hasan Majdi,6 Reza Najjar,7 Tahereh Javaheri,8 Peyman Zare9

1Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz 9841, Iran; 2Student Research Committee, Tabriz University of Medical Sciences, Tabriz 9841, Iran; 3Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz 9841, Iran; 4Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz 9841, Iran; 5Nano Drug Delivery Research Center (NDDRC), Kermanshah University of Medical Sciences, Kermanshah 9883, Iran; 6Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz 9841, Iran; 7Polymer Research Laboratory, Faculty of Chemistry, University of Tabriz, Tabriz 9841, Iran; 8Ludwig Boltzmann Institute for Cancer Research, Vienna 1090, Austria; 9Faculty of Medicine, Cardinal Stefan Wyszyński University in Warsaw, Warsaw 01-938, Poland

Correspondence: Tahereh Javaheri
Ludwig Boltzmann Institute for Cancer Research, Institute of Animal Breeding and Genetics, University of Veterinary Medicine, Vienna, Austria
Tel +43-1-25077 563
Fax +43-1-40160 931300
Email zohre.javaheri@gmail.com
Peyman Zare
Faculty of Medicine, Cardinal Stefan Wyszyński University in Warsaw, Warsaw 01-938, Poland
Tel +48884842847
Email Peymanzare33@gmail.com

Abstract: Among the various nano/biomaterials used in cancer treatment, the beauty and benefits of DNA nanocomposites are outstanding. The specificity and programmability of the base pairing of DNA strands, together with their ability to conjugate with different types of functionalities have realized unsurpassed potential for the production of two- and three-dimensional nano-sized structures in any shape, size, surface chemistry and functionality. This review aims to provide an insight into the diversity of static DNA nanodevices, including DNA origami, DNA polyhedra, DNA origami arrays and bioreactors, DNA nanoswitch, DNA nanoflower, hydrogel and dendrimer as young but promising platforms for cancer theranostics. The utility and potential of the individual formats in biomedical science and especially in cancer therapy will be discussed.

Keywords: static DNA nanostructures, cancer treatment, biosensing

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