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Spotlight on botulinum toxin and its potential in the treatment of stroke-related spasticity

Authors Kaku M, Simpson D

Received 3 November 2015

Accepted for publication 12 January 2016

Published 8 March 2016 Volume 2016:10 Pages 1085—1099

DOI https://doi.org/10.2147/DDDT.S80804

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Rasika Samarasinghe

Peer reviewer comments 3

Editor who approved publication: Prof. Dr. Wei Duan


Michelle Kaku, David M Simpson

Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA

Abstract: Poststroke spasticity affects up to one-half of stroke patients and has debilitating effects, contributing to diminished activities of daily living, quality of life, pain, and functional impairments. Botulinum toxin (BoNT) is proven to be safe and effective in the treatment of focal poststroke spasticity. The aim of this review is to highlight BoNT and its potential in the treatment of upper and lower limb poststroke spasticity. We review evidence for the efficacy of BoNT type A and B formulations and address considerations of optimal injection technique, patient and caregiver satisfaction, and potential adverse effects of BoNT.

Keywords: poststroke spasticity, botulinum toxin, onabotulinumtoxinA, incobotulinumtoxinA, rimabotulinumtoxinB
 

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